CORRELATION BETWEEN SERUM LEVEL OF ENDOTHELIN I, PORTAL HYPERTENSION AND HEPATOPULMONARY SYNDROME AMONG CIRRHOTIC PATIENTS

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KHOUSHBATEN M.; JAFARINIA N.; ANSARIN KH.; FATEMI R.; SHARIFIAN A.; KHORAMI Z.; TALEBIPOUR B.; ZALI MOHAMMAD REZA

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Journal: Researcher Bulletin of Medical Sciences Year:2008 | Volume:13 | Issue:3 (63) Page(s): 175-182

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Title

CORRELATION BETWEEN SERUM LEVEL OF ENDOTHELIN I, PORTAL HYPERTENSION AND HEPATOPULMONARY SYNDROME AMONG CIRRHOTIC PATIENTS

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Keywords

CIRRHOSISQ3

HEPATOPULMONARY SYNDROMEQ3

ENDOTHELIN IQ3

PORTAL HYPERTENSIONQ3

Abstract

Background: Increased ENDOTHELIN I (ETI) activity may contribute to the complications of, CIRRHOSIS and PORTAL HYPERTENSION. The main aim of this study was to determine the role of ENDOTHELIN I in cirrhotic patient with portal hypertention and HEPATOPULMONARY SYNDROME.Materials and Methods: Fifty patients with biopsy proven CIRRHOSIS and 50 normal healthy controls were selected for study. After getting informed consent, two dimensional echocardiography, chest x-ray and pulmonary function test have been done for all cirrhotic patients; Patients with cardiac and pulmonary disease history were excluded from the study and the cirrhotic patients who had proved to have intra-pulmonary vascular dilatation in their contrast echocardiogram were classified as the positive HPS.Results: A total of 100 subject (60 males and 40 females in both case and control group) enrolled in the study. Among cirrhotic patients, 10 subjects with clinical and 7 subjects with sub clinical HPS were detected. The most common etiology of CIRRHOSIS was HBV.Hepatopulmonary syndrome was significantly higher in class C (P=0.007). There was no significant difference between plasma Et I level in both clinical and subclinical HPS compared to other cirrhotic patients. ET I levels in cirrhotic patients (2.29 pg/ml) were significantly higher in cirrhotic patients compared to that of normal healthy controls (0.85 pg/ml) (P = 0.038).Conclusion: The effects of HPS on cirrhotic patient’s survival are unclear. As to other studies, we found significant increase in plasma Et I level in cirrhotic patients rather that normal subjects, but in contrast to previous study we found no relation between Et I level and HPS. Only further studies with further numbers of CIRRHOSIS-caused HPS patients may bridge up the gap between scientific effort and credibility in this field.

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APA: Copy

KHOUSHBATEN, M., JAFARINIA, N., ANSARIN, KH., FATEMI, R., SHARIFIAN, A., KHORAMI, Z., TALEBIPOUR, B., & ZALI, MOHAMMAD REZA. (2008). CORRELATION BETWEEN SERUM LEVEL OF ENDOTHELIN I, PORTAL HYPERTENSION AND HEPATOPULMONARY SYNDROME AMONG CIRRHOTIC PATIENTS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 13(3 (63)), 175-182. SID. https://sid.ir/paper/18221/en

Vancouver: Copy

KHOUSHBATEN M., JAFARINIA N., ANSARIN KH., FATEMI R., SHARIFIAN A., KHORAMI Z., TALEBIPOUR B., ZALI MOHAMMAD REZA. CORRELATION BETWEEN SERUM LEVEL OF ENDOTHELIN I, PORTAL HYPERTENSION AND HEPATOPULMONARY SYNDROME AMONG CIRRHOTIC PATIENTS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2008;13(3 (63)):175-182. Available from: https://sid.ir/paper/18221/en

IEEE: Copy

M. KHOUSHBATEN, N. JAFARINIA, KH. ANSARIN, R. FATEMI, A. SHARIFIAN, Z. KHORAMI, B. TALEBIPOUR, and MOHAMMAD REZA ZALI, “CORRELATION BETWEEN SERUM LEVEL OF ENDOTHELIN I, PORTAL HYPERTENSION AND HEPATOPULMONARY SYNDROME AMONG CIRRHOTIC PATIENTS,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 13, no. 3 (63), pp. 175–182, 2008, [Online]. Available: https://sid.ir/paper/18221/en

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