WHETHER HISTAMINE IS INVOLVED IN MIGRAINE HEADACHE OR NOT?

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POURPAK Z.; AHMADIANI A.; GAZERANI P.; MOLAHAJIAN L.; HEMATI A.

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Journal: Researcher Bulletin of Medical Sciences Year:2000 | Volume:5 | Issue:2 (18) Page(s): 165-172

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Title

WHETHER HISTAMINE IS INVOLVED IN MIGRAINE HEADACHE OR NOT?

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Keywords

MIGRAINEQ3

HISTAMINEQ4

NITRIC OXIDEQ3

Abstract

Although recent studies have focused on finding the major molecule involved in MIGRAINE, but its exact molecular mechanism has not been clarified yet. Based on human headache models (GTN and HISTAMINE), it has been proposed that HISTAMINE may play a role through affecting cerebral endothelial H1- receptors followed by NO release. In addition, there are more recent studies showing that MIGRAINE is due to HISTAMINE release from mast cells, which are often in close vicinity of neurons where they are activated by neuropeptides and in response release NITRIC OXIDE. Since there was no report on parallel alteration of HISTAMINE and NITRIC OXIDE in biological fluids of MIGRAINE sufferers, therefore we decided to determine the role of HISTAMINE in MIGRAINE-associated pain (lonely or via NO). For this purpose, we measured serum HISTAMINE level by an improved fluorometric method and serum NO level by Griess method in pain and no-pain phases of MIGRAINE attack. These results showed that there is a significant increase in serum HISTAMINE level in pain and no-pain stages of patients compared with control group and in contrast, serum NO level in MIGRAINE sufferers was significantly reduced. These findings may indicate the involvement of these molecules in MIGRAINE pain. In addition, data analysis showed that serum NO level of those patients with a higher serum HISTAMINE level is significantly lower. Thus some kind of relationship exists between these two molecules.

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APA: Copy

POURPAK, Z., AHMADIANI, A., GAZERANI, P., MOLAHAJIAN, L., & HEMATI, A.. (2000). WHETHER HISTAMINE IS INVOLVED IN MIGRAINE HEADACHE OR NOT?. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 5(2 (18)), 165-172. SID. https://sid.ir/paper/18228/en

Vancouver: Copy

POURPAK Z., AHMADIANI A., GAZERANI P., MOLAHAJIAN L., HEMATI A.. WHETHER HISTAMINE IS INVOLVED IN MIGRAINE HEADACHE OR NOT?. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2000;5(2 (18)):165-172. Available from: https://sid.ir/paper/18228/en

IEEE: Copy

Z. POURPAK, A. AHMADIANI, P. GAZERANI, L. MOLAHAJIAN, and A. HEMATI, “WHETHER HISTAMINE IS INVOLVED IN MIGRAINE HEADACHE OR NOT?,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 5, no. 2 (18), pp. 165–172, 2000, [Online]. Available: https://sid.ir/paper/18228/en

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