CORRELATION BETWEEN LIVER FUNCTION TESTS AND LIVER INFLAMMATION AND FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS B

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GERAMIZADEH B.; AZAR FIRA N.; MOIENI S.R.

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Journal: Researcher Bulletin of Medical Sciences Year:2002 | Volume:7 | Issue:1 (27) Page(s): 57-60

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Title

CORRELATION BETWEEN LIVER FUNCTION TESTS AND LIVER INFLAMMATION AND FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS B

Author(s)

GERAMIZADEH B. | AZAR FIRA N. | MOIENI S.R. | Issue Writer Certificate

Keywords

LIVER FUNCTION TESTQ4

INFLAMMATIONQ4

FIBROSISQ4

HEPATITIS BQ4

Abstract

Background: Chronic HEPATITIS B is one of the major world health problems and there is millions of death because of the cirrhosis and hepatocellular carcinoma, but till now, the only method of estimating the degree of liver INFLAMMATION and FIBROSIS is liver biopsy. There are few controversial reports considering LFT for estimating the degree of liver FIBROSIS and INFLAMMATION, thus we have evaluated the correlation between LIVER FUNCTION TESTs and liver INFLAMMATION and FIBROSIS in patients with chronic HEPATITIS B. Materials and methods: It was a retrospective study. All of the HEPATITIS B patients (confirmed by biopsy) who have had previous LFT tests were included. A pathologist who was unaware of the patients' LFT evaluated INFLAMMATION and FIBROSIS in accordance to Sheuer and Ishaks's classification. Results: Of a total of 139 patients, 42 were excluded due to accompanying diseases other than HEPATITIS B. The remaining 97 patients were included 57 males and 40 females with the mean age of 35.9 years (15-66). The mean interval between liver biopsy and LFT test was 4.2 days, where in more than 90% it was less than one week. AL T and total bilirubin had shown significant correlation with grade of INFLAMMATION (p<0.005). The most coefficient correlation was between grade and AST/ALT ratio that had reverse relation (p<0.01). Meanwhile, FIBROSIS revealed to have significant correlation with AL T, total bilirubin, and globulin. Conclusion: Despite the presence of significant correlation, liver biopsy is still the most reliable method of estimating the degree of FIBROSIS and INFLAMMATION.

Cites

THE RELATIONSHIP BETWEEN SERUM LEVELS OF HEPATIC TRANSAMINASE WITH HISTOPATHOLOGICAL FEATURES IN PATIENTS WITH CHRONIC HEPATITIS B

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APA: Copy

GERAMIZADEH, B., AZAR FIRA, N., & MOIENI, S.R.. (2002). CORRELATION BETWEEN LIVER FUNCTION TESTS AND LIVER INFLAMMATION AND FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS B. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 7(1 (27)), 57-60. SID. https://sid.ir/paper/18261/en

Vancouver: Copy

GERAMIZADEH B., AZAR FIRA N., MOIENI S.R.. CORRELATION BETWEEN LIVER FUNCTION TESTS AND LIVER INFLAMMATION AND FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS B. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2002;7(1 (27)):57-60. Available from: https://sid.ir/paper/18261/en

IEEE: Copy

B. GERAMIZADEH, N. AZAR FIRA, and S.R. MOIENI, “CORRELATION BETWEEN LIVER FUNCTION TESTS AND LIVER INFLAMMATION AND FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS B,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 7, no. 1 (27), pp. 57–60, 2002, [Online]. Available: https://sid.ir/paper/18261/en

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