EFFECTS OF BUPIVACAIN INFILTRATION ON INSULIN, GLUCOSE, PROLACTIN AND CORTISOL RESPONSES TO OPERATIVE STRESS AFTER UNILATERAL INGUINAL HERNOIRAPHY AMONG 3-7 YEAR-OLD CHILDREN

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ROUZROKH MOHSEN; SADEGHI AFSANEH; GHARIB A.; ADLKHOU H.; SALEHPOUR SH.; TAVASOLI AZITA; AZARGASHB E.A.; SHAYEGHI SH.; KHALEGHNEZHAD TABARI A.; SADEGHIAN N.; KOURANLOU J.; AMIR FEYZ M.; ABD ELAH GORJI F.

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Journal: Researcher Bulletin of Medical Sciences Year:2009 | Volume:13 | Issue:6 (66) Page(s): 505-512

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Title

EFFECTS OF BUPIVACAIN INFILTRATION ON INSULIN, GLUCOSE, PROLACTIN AND CORTISOL RESPONSES TO OPERATIVE STRESS AFTER UNILATERAL INGUINAL HERNOIRAPHY AMONG 3-7 YEAR-OLD CHILDREN

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Keywords

LOCAL ANESTHESISAQ3

INFILTRATIONQ3

INGUINAL HERNIAQ2

CHILDRENQ3

BUPIVACAINQ3

STRESS HORMONESQ3

Abstract

Background: Operative stress and post-operative pain are important issues in medicine. After any types of surgery, the STRESS HORMONES release responding to pain In this study we applied BUPIVACAIN INFILTRATION in surgical wounds of INGUINAL HERNIA amongst CHILDREN aged 3-7 years and evaluated its effects on some STRESS HORMONES and plasma levels of glucose.Materials and Methods: In this prospective study, 116 CHILDREN aged 3-7 years (24 females, 92 males) undergone unilateral repair of INGUINAL HERNIA under general anesthesia at Mofid CHILDREN hospital during 2005-2007, were divided into 2 groups. Perincisional wound INFILTRATION of 1-2 mg/kg of BUPIVACAIN was performed in experimental group. In both groups, 10-15 mg/kg of Acetaminophen suppository were recommended at the recovery room. 4 ml of blood samples were obtained at three distinct stages (preincisional stage, at the end of operation and 4 hours after operation) to measure the insulin, prolactin cortisol and glucose plasma levels of subjects. Post operative pain was measured objectively by Hannalla scale.Results: In both groups plasma prolactin levels increased at the end of operation along with insulin, cortisol and glucose. However, these differences became statistically significant just for insulin. There were no significant differences between other variables. In addition, although the plasma concentration of above mentioned variables became lesser in the 4th hour of post-operative period in experimental group, there was no statistically significant difference compared to the those of control group.Conclusion: Wound INFILTRATION of BUPIVACAIN decreases the STRESS HORMONES and pain during the post-operative period. We recommend this type of INFILTRATION applying long-acting anesthetic agents with fewer numbers of side-effects.

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APA: Copy

ROUZROKH, MOHSEN, SADEGHI, AFSANEH, GHARIB, A., ADLKHOU, H., SALEHPOUR, SH., TAVASOLI, AZITA, AZARGASHB, E.A., SHAYEGHI, SH., KHALEGHNEZHAD TABARI, A., SADEGHIAN, N., KOURANLOU, J., AMIR FEYZ, M., & ABD ELAH GORJI, F.. (2009). EFFECTS OF BUPIVACAIN INFILTRATION ON INSULIN, GLUCOSE, PROLACTIN AND CORTISOL RESPONSES TO OPERATIVE STRESS AFTER UNILATERAL INGUINAL HERNOIRAPHY AMONG 3-7 YEAR-OLD CHILDREN. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 13(6 (66)), 505-512. SID. https://sid.ir/paper/18304/en

Vancouver: Copy

ROUZROKH MOHSEN, SADEGHI AFSANEH, GHARIB A., ADLKHOU H., SALEHPOUR SH., TAVASOLI AZITA, AZARGASHB E.A., SHAYEGHI SH., KHALEGHNEZHAD TABARI A., SADEGHIAN N., KOURANLOU J., AMIR FEYZ M., ABD ELAH GORJI F.. EFFECTS OF BUPIVACAIN INFILTRATION ON INSULIN, GLUCOSE, PROLACTIN AND CORTISOL RESPONSES TO OPERATIVE STRESS AFTER UNILATERAL INGUINAL HERNOIRAPHY AMONG 3-7 YEAR-OLD CHILDREN. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2009;13(6 (66)):505-512. Available from: https://sid.ir/paper/18304/en

IEEE: Copy

MOHSEN ROUZROKH, AFSANEH SADEGHI, A. GHARIB, H. ADLKHOU, SH. SALEHPOUR, AZITA TAVASOLI, E.A. AZARGASHB, SH. SHAYEGHI, A. KHALEGHNEZHAD TABARI, N. SADEGHIAN, J. KOURANLOU, M. AMIR FEYZ, and F. ABD ELAH GORJI, “EFFECTS OF BUPIVACAIN INFILTRATION ON INSULIN, GLUCOSE, PROLACTIN AND CORTISOL RESPONSES TO OPERATIVE STRESS AFTER UNILATERAL INGUINAL HERNOIRAPHY AMONG 3-7 YEAR-OLD CHILDREN,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 13, no. 6 (66), pp. 505–512, 2009, [Online]. Available: https://sid.ir/paper/18304/en

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