SAFFRON CAROTENOID EFFECTS ON THE POLYMERIZATION OF MICROTUBULES AND HELA CELL GROWTH

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ALIJANIANZADEH M.; ZAREI JALIANI H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Paper Information

Journal: BIOLOGICAL SCIENCES (DANISH-I ZISTI-I IRAN) Year:2009 | Volume:4 | Issue:1 Page(s): 31-39

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Information Journal Paper

Title

SAFFRON CAROTENOID EFFECTS ON THE POLYMERIZATION OF MICROTUBULES AND HELA CELL GROWTH

Author(s)

ALIJANIANZADEH M. | ZAREI JALIANI H. | Issue Writer Certificate

Keywords

CROCINQ2

TUBULINQ2

MICROTUBULEQ3

INTRINSIC FLUORESCENCE SPECTRAQ3

Abstract

Saffron carotenoids have attracted research interests during recent decades. CROCIN exists in saffron and has shown anti-tumor activity both in vitro and in vivo. Microtubular proteins have several functions in nearly all kinds of the cells such as cellular transport, cell motility and mitosis. In neurons MICROTUBULEs are involved in neurotransmitter transport. CROCIN interacts with cellular proteins and modulates their functions, but the exact targets of this carotenoid and the other compounds of the saffron have not been discovered yet. In this study we showed that the CROCIN affected the TUBULIN polymerization and the structure by using the ultraviolet spectrophotometry and fluorometry. Fluorescence spectroscopic data showed that significant conformational changes were produced in TUBULIN in presence of CROCIN. Ultraviolet spectroscopy indicated that CROCIN increased polymerization of the TUBULIN. The aim of this study was to investigate whether CROCIN affects the cell proliferation and other cellular processes through cytoskeletal protein TUBULIN. The results can lead us to characterize the reole of CROCIN in cell proliferation as an opportunity to use this compound in cabcer therapy.

Cites

OPTIMISATION AND EVALUATION OF SAFFRON EXTRACTION CONDITIONS IN THE BINARY AND TERNARY SOLVENT SYSTEMS

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APA: Copy

ALIJANIANZADEH, M., & ZAREI JALIANI, H.. (2009). SAFFRON CAROTENOID EFFECTS ON THE POLYMERIZATION OF MICROTUBULES AND HELA CELL GROWTH. BIOLOGICAL SCIENCES (DANISH-I ZISTI-I IRAN), 4(1), 31-39. SID. https://sid.ir/paper/183721/en

Vancouver: Copy

ALIJANIANZADEH M., ZAREI JALIANI H.. SAFFRON CAROTENOID EFFECTS ON THE POLYMERIZATION OF MICROTUBULES AND HELA CELL GROWTH. BIOLOGICAL SCIENCES (DANISH-I ZISTI-I IRAN)[Internet]. 2009;4(1):31-39. Available from: https://sid.ir/paper/183721/en

IEEE: Copy

M. ALIJANIANZADEH, and H. ZAREI JALIANI, “SAFFRON CAROTENOID EFFECTS ON THE POLYMERIZATION OF MICROTUBULES AND HELA CELL GROWTH,” BIOLOGICAL SCIENCES (DANISH-I ZISTI-I IRAN), vol. 4, no. 1, pp. 31–39, 2009, [Online]. Available: https://sid.ir/paper/183721/en

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