PREVALENCE OF CONGENITAL HEART DISEASE AND THYROID DYSFUNCTION AND ITS ASSOCIATED FACTORS IN DOWN SYNDROME

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MOJTAHEDZADEH S.; SAYAH FAR SH.

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Journal: Researcher Bulletin of Medical Sciences Year:2003 | Volume:8 | Issue:2 (32) Page(s): 87-90

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Title

PREVALENCE OF CONGENITAL HEART DISEASE AND THYROID DYSFUNCTION AND ITS ASSOCIATED FACTORS IN DOWN SYNDROME

Author(s)

MOJTAHEDZADEH S. | SAYAH FAR SH. | Issue Writer Certificate

Keywords

DOWN SYNDROMEQ4

THYROID DYSFUNCTIONQ4

CONGENITAL HEART DISEASEQ2

Abstract

Background: Many body organs, particularly heart and thyroid, are involved in DOWN SYNDROME. Regarding various reports of prevalence rate of CONGENITAL HEART DISEASE and thyroid gland dysfunction in this syndrome, as well as lack of informative data in Iran, and in order to determine the prevalence rate of CONGENITAL HEART DISEASE and THYROID DYSFUNCTION in Down patients, the present study was conducted on 120 Down patients invited from Iranian DOWN SYNDROME society as well as exceptional schools throughout city of Tehran in year 2001. Materials and methods: For this descriptive study patients aged between 2 months and 20 years were studied. Diagnosis of DOWN SYNDROME was made in accordance to karyotype or apparent symptoms of this syndrome. Then, they were examined for goiter. CONGENITAL HEART DISEASEs were identified by echocardiography, and THYROID DYSFUNCTION was assessed by blood tests including TSH, T4 and T3. Results: The study population included 50 boys and 70 girls with the mean age of 10.1±5 years. The prevalence rate of goiter was estimated 5%. Subclinical hypothyroidism, clinical hypothyroidism, subclinical hyperthyroidism, and clinical hyperthyroidism were revealed in 8.8, 11.5, 2.6, and 2.6%, respectively.Congenital heart diseases (CHD) were observed in 55 individuals (46%), among which 36.4% had pulmonary hypertension. The most frequent CONGENITAL HEART DISEASE was VSD (17.5%). Also it was found that the age of mother plays a role in developing CONGENITAL HEART DISEASEs in these patients.Conclusion: The prevalence rate of CONGENITAL HEART DISEASE is very close to other studies, however, the prevalence rate of THYROID DYSFUNCTION is either close to or higher than other studies. Moreover, these disorders are more commonly seen in Down patients than the normal population. Therefore, concerning the high prevalence rate of CHD and thyroid disorders in patients with DOWN SYNDROME, and with respect to the complications associated with these diseases, we strongly recommend that patients with DOWN SYNDROME should be evaluated for CHD and thyroid problems during the neonatal period.

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APA: Copy

MOJTAHEDZADEH, S., & SAYAH FAR, SH.. (2003). PREVALENCE OF CONGENITAL HEART DISEASE AND THYROID DYSFUNCTION AND ITS ASSOCIATED FACTORS IN DOWN SYNDROME. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 8(2 (32)), 87-90. SID. https://sid.ir/paper/18379/en

Vancouver: Copy

MOJTAHEDZADEH S., SAYAH FAR SH.. PREVALENCE OF CONGENITAL HEART DISEASE AND THYROID DYSFUNCTION AND ITS ASSOCIATED FACTORS IN DOWN SYNDROME. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2003;8(2 (32)):87-90. Available from: https://sid.ir/paper/18379/en

IEEE: Copy

S. MOJTAHEDZADEH, and SH. SAYAH FAR, “PREVALENCE OF CONGENITAL HEART DISEASE AND THYROID DYSFUNCTION AND ITS ASSOCIATED FACTORS IN DOWN SYNDROME,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 8, no. 2 (32), pp. 87–90, 2003, [Online]. Available: https://sid.ir/paper/18379/en

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