SYNTHESIS OF GEMFIBROZIL

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SHAHHOSSEINI S.; HOUSHDAR TEHRANI M.H.; HAJI ASHRAFI A.; SOLEYMANI ZOHREH

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Journal: Researcher Bulletin of Medical Sciences Year:2002 | Volume:6 | Issue:5 (25) Page(s): 437-440

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Title

SYNTHESIS OF GEMFIBROZIL

Author(s)

SHAHHOSSEINI S. | HOUSHDAR TEHRANI M.H. | HAJI ASHRAFI A. | SOLEYMANI ZOHREH | Issue Writer Certificate

Keywords

GEMFIBROZILQ4

SYNTHESISQ4

Abstract

Background: Nowadays, the major causes of death are attributed to vascular disease, of which the most important form is atherosclerotic heart disease. Some prevalent causative factors are smoking, stress, obesity, and high level of lipids in serum. Atherosclerotic disease could be treated either by medical therapy or diet. Clofibrate and its analogs are highly effective drugs used to reduce serum cholesterol.Materials and methods: It was an explorative study. Having the isobutiric acid, 1,3 dibromo propane, and 2,5 dimethyl phenol purchased from Fluka company and isobutanol, dioxane, dimethyl sulfoxide, diisopropylamin and tetrahydrofuran purchased from Merck company, the procedure was performed.Results: GEMFIBROZIL [5-(2,5 dimethyl phenoxy) 2,2 di pentanoic acid] was synthesized through Williamson method. Its reported yield and purity were 70% and 80%, respectively.Conclusion: Method that is explained in this article, is by far the most suitable way of GEMFIBROZIL SYNTHESIS due to its simplicity, price, yield (70%), purity(80%), and scale up.

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APA: Copy

SHAHHOSSEINI, S., HOUSHDAR TEHRANI, M.H., HAJI ASHRAFI, A., & SOLEYMANI, ZOHREH. (2002). SYNTHESIS OF GEMFIBROZIL. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 6(5 (25)), 437-440. SID. https://sid.ir/paper/18518/en

Vancouver: Copy

SHAHHOSSEINI S., HOUSHDAR TEHRANI M.H., HAJI ASHRAFI A., SOLEYMANI ZOHREH. SYNTHESIS OF GEMFIBROZIL. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2002;6(5 (25)):437-440. Available from: https://sid.ir/paper/18518/en

IEEE: Copy

S. SHAHHOSSEINI, M.H. HOUSHDAR TEHRANI, A. HAJI ASHRAFI, and ZOHREH SOLEYMANI, “SYNTHESIS OF GEMFIBROZIL,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 6, no. 5 (25), pp. 437–440, 2002, [Online]. Available: https://sid.ir/paper/18518/en

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