Microglia: Structure, Function, and Role in the CNS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Behzad Basirat Amir Mohammad; Behzad Basirat Zahra; Rezaei Kia Fatemeh; Ebrahimi Safieh; Gorji Ali

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Neuroscience Journal of Shefaye Khatam Year:2025 | Volume:13 | Issue:4 Page(s): 91-111

Download Full-Text

Persian Verion

View:

Download:

Cites:

Information Journal Paper

Title

Microglia: Structure, Function, and Role in the CNS

Author(s)

Keywords

Neuroinflammatory Diseases

Cytokines

Immunity

Innate

Phagocytosis

Abstract

Introduction: The proper development and function of the central nervous system (CNS) depends fundamentally on the activity of parenchymal sentinels called microglia. Microglia currently have the greatest ability and capability compared to other cells in the CNS, with the capacity to adapt morphologically and functionally to their changing environment. Even at rest, microglia cells are highly dynamic and constantly survey the condition in the CNS. Following injury, these cells rapidly change morphology and migrate towards the site of injury. Any injury to the CNS is accompanied by the release of mediators that serve as signals for the activation or chemotaxis of microglia. They can communicate with neurons, astrocytes, and other cells of the immune system through a large number of signaling pathways. Microglia are critical contributors to the homeostasis of the CNS and dysregulation of these cells contributes to the pathophysiology of neurodegenerative diseases. Conclusion: microglia are crucial to maintaining CNS homeostasis through their dynamic rapid response to insults. Their ability to interact with various cell types and adapt to environmental changes points to their important role in CNS pathologies, including brain tumors, and neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and Amyotrophic lateral sclerosis.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans