مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

A 58-year-old patient with acute lymphocytic leukemia with methotrexate-induced leukoencephalopathy

Pages

  276-278

Abstract

Methotrexate (MTX) is a folic acid antagonist and is one of the most commonly utilized chemotherapeutics in cancer treatment. 1 MTXrelated neurotoxicity occurs in only 3. 1%-3. 8% of cases and manifests with acutely and clinically alarming symptoms. 2 These symptoms can be mistaken for other etiologies such as stroke, seizure, headache, and disorientation. 2-5 Due to the ambiguous presentation, differentiation and diagnosis are extremely critical yet incredibly challenging in an emergency department (ED) setting. This case will discuss the treatment and outcomes of a patient who was diagnosed with leukoencephalopathy due to MTX toxicity.

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