LIVER STEATOSIS AND CHRONIC HEPATITIS-B INFECTION: VIRAL AND HOST RISK FACTORS

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MINAKARI MOHAMMAD; MOULAEI M.; MOHAGHEGH SHALMANI H.; MOHAMMADALIZADEH A.H.; NADERI N.A.; MASHAYEKHI R.; ZALI MOHAMMAD REZA

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Journal: Researcher Bulletin of Medical Sciences Year:2007 | Volume:12 | Issue:4 (58) Page(s): 313-318

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Title

LIVER STEATOSIS AND CHRONIC HEPATITIS-B INFECTION: VIRAL AND HOST RISK FACTORS

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Keywords

HEPATITIS BQ3

STEATOSISQ3

CHRONIC LIVER DISEASEQ3

Abstract

Background: Liver STEATOSIS and chronic HEPATITIS B infection are the most common causes of CHRONIC LIVER DISEASEs in Iran. There have been a a limited number of studies throughout the world, evaluating the association of HEPATITIS B infection and STEATOSIS. We studied the association between some of viral and host factors and the presence of STEATOSIS among patients with chronic HEPATITIS B infection.Materials and Methods: In this analytical cross-sectional study, 71 patients with chronic HEPATITIS B infection were preliminarily assessed by liver biopsy. The patients were divided into two groups based on either presence or absence of STEATOSIS in liver tissue. These two groups were compared in terms of different host and viral factors along with their stage of fibrosis. Results: Of 71 patients, 30 (42.3%) had significant STEATOSIS (in >5% of hepatocytes, according to Brunt classification). Sex and gender were not significantly different in 2 groups. The mean BMI, serum levels of FBS, cholesterol, TG, GGT, were significantly higher in STEATOSIS group compared to those of non-steatosis one (P<0.05). In contrast, the mean levels of AST, ALT, ALK-P were not significantly different in these groups. The frequency of HBeAg positivity and the mean level of viral load of two groups had no significant difference. There was also no significant difference in the mean stages of fibrosis between two groups.Conclusion: It seems that certain metabolic hosts factors such as BMI, FBS, cholesterol, TG, GGT are associated with STEATOSIS in patients with chronic HEPATITIS B infection while such an association was not found with the evaluated viral factors. We suggest further investigations to evaluate the role of other factors (such as HBV genotype) in the future.

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APA: Copy

MINAKARI, MOHAMMAD, MOULAEI, M., MOHAGHEGH SHALMANI, H., MOHAMMADALIZADEH, A.H., NADERI, N.A., MASHAYEKHI, R., & ZALI, MOHAMMAD REZA. (2007). LIVER STEATOSIS AND CHRONIC HEPATITIS-B INFECTION: VIRAL AND HOST RISK FACTORS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 12(4 (58)), 313-318. SID. https://sid.ir/paper/18549/en

Vancouver: Copy

MINAKARI MOHAMMAD, MOULAEI M., MOHAGHEGH SHALMANI H., MOHAMMADALIZADEH A.H., NADERI N.A., MASHAYEKHI R., ZALI MOHAMMAD REZA. LIVER STEATOSIS AND CHRONIC HEPATITIS-B INFECTION: VIRAL AND HOST RISK FACTORS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2007;12(4 (58)):313-318. Available from: https://sid.ir/paper/18549/en

IEEE: Copy

MOHAMMAD MINAKARI, M. MOULAEI, H. MOHAGHEGH SHALMANI, A.H. MOHAMMADALIZADEH, N.A. NADERI, R. MASHAYEKHI, and MOHAMMAD REZA ZALI, “LIVER STEATOSIS AND CHRONIC HEPATITIS-B INFECTION: VIRAL AND HOST RISK FACTORS,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 12, no. 4 (58), pp. 313–318, 2007, [Online]. Available: https://sid.ir/paper/18549/en

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