COMPARATIVE CLINICAL EFFICASY AND SAFETY OF TICLOPIDINE AND CLOPIDOGREL FOLLOWING CORONARY STENT- ANGIOPLASTY

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NAMAZI M.H.; JAFARI PHESHARAKI M.; GHOBADI O.; VALAEI NASER

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Journal: Researcher Bulletin of Medical Sciences Year:2004 | Volume:9 | Issue:4 (40) Page(s): 187-190

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Title

COMPARATIVE CLINICAL EFFICASY AND SAFETY OF TICLOPIDINE AND CLOPIDOGREL FOLLOWING CORONARY STENT- ANGIOPLASTY

Author(s)

NAMAZI M.H. | JAFARI PHESHARAKI M. | GHOBADI O. | VALAEI NASER | Issue Writer Certificate

Keywords

TICLOPIDINEQ4

CLOPIDOGRELQ4

ANGIOPLASTYQ3

CORONARY STENTQ3

Abstract

Background: Coronary artery disease is the most common cause of death worldwide and ANGIOPLASTY is one of the most effective modality of treatment. TICLOPIDINE and CLOPIDOGREL, as antiplatelet drugs, have been used to prevent the development of recurrent stenosis in these patients. The aim of this study was comparison of drugs efficacy and side effects in CORONARY STENT patients. Materials and methods: In this sequential randomized double blind clinical trial, the effectiveness and cardiac & non-cardiac side effects of two antiplatelet drugs (clopidogrel & TICLOPIDINE) were compared. All patients regardless age or number of diseased coronary arteries who underwent sent ANGIOPLASTY between Feb. 2000 – Feb. 2002 in Shaheed Modarres hospital were randomly divided between two groups. Patients in case group received TICLOPIDINE + ASA and controls received clopiogrel + ASA for a month. During the period of 3 months follow up, all patients were evaluated for GI, skin, cardiovascular and hematological complications by means of direct examination, periodic CBC(every 2 weeks) and exercise test (after 8 months). Results: Follow up of 196 patients was completed. Regarding cardiac events (ie: MI, Unstable angina, Abrupt closure and death) no significant difference was noted between two groups. Although leukopenia, thrombocytopenia, bleeding, GI & skin cruptions were more frequent in TICLOPIDINE group but these differences were not statistiacally significant. Number of restenosis cases (following angiography) was equal between two groups which was comparable with other studies. Conclusion: On the basis of results, there wasn't any superiorty of CLOPIDOGREL to TICLOPIDINE. Of course the study should continue to cover adequate sample size for final analysis.

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APA: Copy

NAMAZI, M.H., JAFARI PHESHARAKI, M., GHOBADI, O., & VALAEI, NASER. (2004). COMPARATIVE CLINICAL EFFICASY AND SAFETY OF TICLOPIDINE AND CLOPIDOGREL FOLLOWING CORONARY STENT- ANGIOPLASTY. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 9(4 (40)), 187-190. SID. https://sid.ir/paper/18597/en

Vancouver: Copy

NAMAZI M.H., JAFARI PHESHARAKI M., GHOBADI O., VALAEI NASER. COMPARATIVE CLINICAL EFFICASY AND SAFETY OF TICLOPIDINE AND CLOPIDOGREL FOLLOWING CORONARY STENT- ANGIOPLASTY. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2004;9(4 (40)):187-190. Available from: https://sid.ir/paper/18597/en

IEEE: Copy

M.H. NAMAZI, M. JAFARI PHESHARAKI, O. GHOBADI, and NASER VALAEI, “COMPARATIVE CLINICAL EFFICASY AND SAFETY OF TICLOPIDINE AND CLOPIDOGREL FOLLOWING CORONARY STENT- ANGIOPLASTY,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 9, no. 4 (40), pp. 187–190, 2004, [Online]. Available: https://sid.ir/paper/18597/en

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