HISTORICAL COHORT STUDY OF BREAST IRRADIATION SCHEDULES AFTER MODIFIED RADICAL MASTECTOMY (MRM) FOR WOMEN WITH BREAST CANCER

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

FAZL ALIZADEH A.; HATAMI E.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Researcher Bulletin of Medical Sciences Year:2004 | Volume:9 | Issue:4 (40) Page(s): 209-214

Download Full-Text

Persian Verion

View:

2,358

Download:

Cites:

Information Journal Paper

Title

HISTORICAL COHORT STUDY OF BREAST IRRADIATION SCHEDULES AFTER MODIFIED RADICAL MASTECTOMY (MRM) FOR WOMEN WITH BREAST CANCER

Author(s)

FAZL ALIZADEH A. | HATAMI E. | Issue Writer Certificate

Keywords

BREAST CANCERQ2

SHORT COUSE RADIOTHERAPYQ4

LOCAL RECURRENCEQ4

Abstract

Background: Breast irradiation after MRM is an integral component in patients with high loco regional recurrence of BREAST CANCER. Because an optimal fractionation schedule (radiation dose given in a specified number of fractions or treatment sessions over a defined time) for breast irradiation has not been uniformly accepted, we examined whether a 21-day fractionation schedule was as effective as the more traditional 35-day schedule in reducing recurrence. Materials and methods: 100 women with invasive carcinoma of the breast treated by MRM that referred to Imam Hossein and Madaen hospitals for irradiation were studied. 50 patients (case group) received short course radiotherapy (40 Gy in 15 fractions over 21 days) and the control group received traditional radiotherapy (50 Gy in 25 fractions over 35 days). Patients in both groups were matched by age, stage of cancer, laterality, chemotherapy and hormone therapy items. Results: Mean age (±S.E.) in the case group (49.9±10.99) and the control group (49.12±9.74) were similar approximately. Three patients experienced local BREAST CANCER recurrence as a first event during 5 years: 1 in the short treatment arm and 2 in the long treatment arm. LOCAL RECURRENCE-free survival was approximately similar in both groups. During 5 years, LOCAL RECURRENCE-free survival was 98% in short arm and 96% in long arm. In this study, no difference were detected for disease-free survival (P<0.84) or overall survival (P<0.76). Conclusion: Results from this study support the use of a modest increased in daily fraction size for breast irradiation when the total dose and overall treatment time is reduced. This study demonstrates that a shorter fractionation schedule of 40 Gy in 15 fractions over 21 days is as effective as the more traditional schedule of 50 Gy in 25 fractions over 35 days in terms of preventing recurrence of cancer in the breast.

Cites

COMPARING THREE ADJUVANT CHEMOTHERAPY REGIMES AFTER MODIFIED RADICAL MASTECTOMY IN BREAST CANCER PATIENTS USING LOG-LOGISTIC MODEL

References

No record.

Cite

APA: Copy

FAZL ALIZADEH, A., & HATAMI, E.. (2004). HISTORICAL COHORT STUDY OF BREAST IRRADIATION SCHEDULES AFTER MODIFIED RADICAL MASTECTOMY (MRM) FOR WOMEN WITH BREAST CANCER. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 9(4 (40)), 209-214. SID. https://sid.ir/paper/18601/en

Vancouver: Copy

FAZL ALIZADEH A., HATAMI E.. HISTORICAL COHORT STUDY OF BREAST IRRADIATION SCHEDULES AFTER MODIFIED RADICAL MASTECTOMY (MRM) FOR WOMEN WITH BREAST CANCER. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2004;9(4 (40)):209-214. Available from: https://sid.ir/paper/18601/en

IEEE: Copy

A. FAZL ALIZADEH, and E. HATAMI, “HISTORICAL COHORT STUDY OF BREAST IRRADIATION SCHEDULES AFTER MODIFIED RADICAL MASTECTOMY (MRM) FOR WOMEN WITH BREAST CANCER,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 9, no. 4 (40), pp. 209–214, 2004, [Online]. Available: https://sid.ir/paper/18601/en

Related Journal Papers