EVALUATION OF SYNERGISTIC EFFECT OF GENTAMICIN AND AMPICILLIN AGAINST IRANIAN STRAINS OF ENTEROCOCCUS FAECALIS

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FEYZABADI M.M.; ASADI S.; OSKOUEI MAHVASH; SHOKRZADEH L.; SAYADI S.

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Journal: Researcher Bulletin of Medical Sciences Year:2007 | Volume:11 | Issue:5 (53) Page(s): 331-335

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Title

EVALUATION OF SYNERGISTIC EFFECT OF GENTAMICIN AND AMPICILLIN AGAINST IRANIAN STRAINS OF ENTEROCOCCUS FAECALIS

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Keywords

SYNERGYQ2

GENTAMICIN RESISTANCEQ3

ENTEROCOCCUS FAECALISQ2

Abstract

Background: Improper prescription of vancomycin is one of the -reasons for emerging resistance of enterococci to this antibiotic. Therefore, such resistance can be reduced if other effective antibiotics such as gentamicin in combination with ampicillin are used against the susceptible strains. The purpose of this study was to evaluate the possible synergistic effect of these antibiotics against isolates of ENTEROCOCCUS FAECALIS that show low level of resistance to gentamicin (MIC<16 mg/ml).Material and Methods: 97 isolates of E. Faecalis (MIC<500) were selected. The SYNERGY test was performed between ampicillin at 1/4 % and 1/2 MIC for each strain and gentamicin at 2 and 4 mg/ml.Results: SYNERGYreslilts showed that gentamicin 4mg/ml was more effective than 2 mg/ml. The most effective concentration of apicillin in SYNERGY experiment was 1/2, of MIC for every strain. The strongest SYNERGY activity was detected among the antibiotic treated cells after a6- hour treatment. Conclusions: The growths of more than 70% of low level gentaniicin resistant (MIC<16 mg/ml) isolates E. Faecalis were inhibited in combined antibiotics consisting of 4 mg/ml, of gentamicin with 1/2 MIC of -ampicillin of each strain. Based on the results it appears that low level gentamicin resistant isolates -are susceptible to, combination therapy with gentamiein and ampicillin, thus they may be a good altemative regimen for vancomyc in and gentamicin.

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APA: Copy

FEYZABADI, M.M., ASADI, S., OSKOUEI, MAHVASH, SHOKRZADEH, L., & SAYADI, S.. (2007). EVALUATION OF SYNERGISTIC EFFECT OF GENTAMICIN AND AMPICILLIN AGAINST IRANIAN STRAINS OF ENTEROCOCCUS FAECALIS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 11(5 (53)), 331-335. SID. https://sid.ir/paper/18614/en

Vancouver: Copy

FEYZABADI M.M., ASADI S., OSKOUEI MAHVASH, SHOKRZADEH L., SAYADI S.. EVALUATION OF SYNERGISTIC EFFECT OF GENTAMICIN AND AMPICILLIN AGAINST IRANIAN STRAINS OF ENTEROCOCCUS FAECALIS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2007;11(5 (53)):331-335. Available from: https://sid.ir/paper/18614/en

IEEE: Copy

M.M. FEYZABADI, S. ASADI, MAHVASH OSKOUEI, L. SHOKRZADEH, and S. SAYADI, “EVALUATION OF SYNERGISTIC EFFECT OF GENTAMICIN AND AMPICILLIN AGAINST IRANIAN STRAINS OF ENTEROCOCCUS FAECALIS,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 11, no. 5 (53), pp. 331–335, 2007, [Online]. Available: https://sid.ir/paper/18614/en

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