THE EFFECT OF ETHANOL ON HISTOLOGICAL STRUCTURE OF DENTATE GYRUS OF HYPOCAMUP IN EPILEPTIC MICE

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GOLMOHAMMADI R.; MOHAMMADZADEH M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Journal of North Khorasan University of Medical Sciences Year:2012 | Volume:4 | Issue:2 (12) Page(s): 229-236

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Title

THE EFFECT OF ETHANOL ON HISTOLOGICAL STRUCTURE OF DENTATE GYRUS OF HYPOCAMUP IN EPILEPTIC MICE

Author(s)

GOLMOHAMMADI R. | MOHAMMADZADEH M. | Issue Writer Certificate

Keywords

ETHANOLQ2

HYPOCAMPQ3

PENTYLENTETRAZOLQ2

MICEQ2

Abstract

Background & objective: In short memory, hippocampus has an important role. Hippocampus is one of the regions of brain which neurogenesis has been shown in adults. In the present study, effect of ETHANOL on histological structure of dentate gyrus (DG) in epileptic MICE was investigated.Materials & Methods: in this experimental study, MICE (25-30g) during chemical kindling (pentylentetrazol; 40 mg/kg) received ETHANOL (0.5, 1 and 2 g/kg body weight) intraperitoneally. After treatment period, hippocampus and DG was dissected out. Histological passage and coronal cross-section was carried out in final. After Hematoxyline-stained slides forty fields random systematic (counting of normal neurons in DG) from each group by photomicroscope (Motic, X400) and Advanced motic plus2 software were studied. The mean number of normal neurons in DG of HYPOCAMPus were analyzes by ANOVA, Dunnett and Duncan. Immunohistochemical method used caspase 3 for program cell death in HYPOCAMPal neurons.Results: Dunnett test showed the number of normal neurons in ETHANOL receiving groups (0.5 g/kg, 7 or 21 days injection) has not been decreased significantly different in comparison with control group (p=0.41 and p=0.07 respectively). The number of normal neurons in groups which received ETHANOL 1g/kg (7 or 21 days injection) has been decreased significantly different in comparison with control group (p=0.014 and p=0.007 respectively). This parameter is also different between ETHANOL 2g/kg group and control group (p<0.001). The apoptosis of HYPOCAMPal neurons in groups which received high dose of ETHANOL 2 g/kg greater.Conclusion: decreasing of the number of normal neurons in DG hippocampus has right relationship with increasing dosage and duration of ETHANOL usage in epileptic MICE.

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APA: Copy

GOLMOHAMMADI, R., & MOHAMMADZADEH, M.. (2012). THE EFFECT OF ETHANOL ON HISTOLOGICAL STRUCTURE OF DENTATE GYRUS OF HYPOCAMUP IN EPILEPTIC MICE. JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES, 4(2 (12)), 229-236. SID. https://sid.ir/paper/186916/en

Vancouver: Copy

GOLMOHAMMADI R., MOHAMMADZADEH M.. THE EFFECT OF ETHANOL ON HISTOLOGICAL STRUCTURE OF DENTATE GYRUS OF HYPOCAMUP IN EPILEPTIC MICE. JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;4(2 (12)):229-236. Available from: https://sid.ir/paper/186916/en

IEEE: Copy

R. GOLMOHAMMADI, and M. MOHAMMADZADEH, “THE EFFECT OF ETHANOL ON HISTOLOGICAL STRUCTURE OF DENTATE GYRUS OF HYPOCAMUP IN EPILEPTIC MICE,” JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES, vol. 4, no. 2 (12), pp. 229–236, 2012, [Online]. Available: https://sid.ir/paper/186916/en

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