THE EFFECT OF OVARIAN HORMONE DELETION ON THE ANALGESIC EFFECT OF MORPHINE IN RATS

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HOSSEINI S.M.; TAYARANI Z.; KARAMI R.; BIBAK B.

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Paper Information

Journal: Journal of North Khorasan University of Medical Sciences Year:2011 | Volume:3 | Issue:1 (7) Page(s): 43-48

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Title

THE EFFECT OF OVARIAN HORMONE DELETION ON THE ANALGESIC EFFECT OF MORPHINE IN RATS

Author(s)

HOSSEINI S.M. | TAYARANI Z. | KARAMI R. | BIBAK B. | Issue Writer Certificate

Keywords

MORPHINEQ2

OVARIECTOMYQ2

PAINQ3

RATQ2

Abstract

Background and Objective: The present study was carried out to evaluate the antinociceptive effect of MORPHINE in ovariectomized female RATs in comparison with naïve and estradiole-treated ovariectomized RATs.Material and Methods: 30 female RATs were divided into 3 groups: 1) Sham (control group) 2) OVX (ovarictomized) 3) OVX Est. (ovarictomized and estradiole treated). Estradiol valerate (2 mg/kg/week, i.m.) was injected in the animals of OVX Est. The animals of Sham and OVX groups received 2ml/kg/week saline instead of estradiole. The hot plate test was carried out as a base record 15 min before injection of MORPHINE (10 mg/kg; S.C.) and consequently it was repeated 5 times, every 15 minutes after injection. The results were compared using one way and repeated-measure analysis of variance (ANOVA) followed by post-hoc Tukey’s test. Differences were considered statistically significant when P<0.05.Results: The reaction times after injection of MORPHINE in sham and OVX Est groups were significantly higher than basal reaction time (P<0.05 and P<0.001) but in OVX group there were no significant differences. However, the reaction times after injection of MORPHINE in OVX, OVX Est and sham groups were not significantly different.Conclusion: It is concluded that ovarian hormones change analgesic effects of MORPHINE in RATs.

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APA: Copy

HOSSEINI, S.M., TAYARANI, Z., KARAMI, R., & BIBAK, B.. (2011). THE EFFECT OF OVARIAN HORMONE DELETION ON THE ANALGESIC EFFECT OF MORPHINE IN RATS. JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES, 3(1 (7)), 43-48. SID. https://sid.ir/paper/187107/en

Vancouver: Copy

HOSSEINI S.M., TAYARANI Z., KARAMI R., BIBAK B.. THE EFFECT OF OVARIAN HORMONE DELETION ON THE ANALGESIC EFFECT OF MORPHINE IN RATS. JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2011;3(1 (7)):43-48. Available from: https://sid.ir/paper/187107/en

IEEE: Copy

S.M. HOSSEINI, Z. TAYARANI, R. KARAMI, and B. BIBAK, “THE EFFECT OF OVARIAN HORMONE DELETION ON THE ANALGESIC EFFECT OF MORPHINE IN RATS,” JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES, vol. 3, no. 1 (7), pp. 43–48, 2011, [Online]. Available: https://sid.ir/paper/187107/en

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