EVALUATION OF DNA DAMAGE AND LIPOPEROXIDATION CONTENT IN RED EARTHWORM, LUMBRICUS RUBELLUS EXPOSED TO ZINC OXIDE NANOPARTICLES

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ARABI MEHRAN; NAJAFI NARGES; JAFARZADEH SAMANI HOMEYRA

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Journal: JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES Year:2013 | Volume:2 | Issue:1 Page(s): 27-31

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Title

EVALUATION OF DNA DAMAGE AND LIPOPEROXIDATION CONTENT IN RED EARTHWORM, LUMBRICUS RUBELLUS EXPOSED TO ZINC OXIDE NANOPARTICLES

Author(s)

ARABI MEHRAN | NAJAFI NARGES | JAFARZADEH SAMANI HOMEYRA | Issue Writer Certificate

Keywords

NANO-ZNOQ1

EARTHWORMQ1

COELOMOCYTEQ1

OXIDATIVE STRESSQ1

DNA DAMAGEQ1

Abstract

Manufactured nanoparticles have a wide range of application due to their advantageous properties when compared with their bulk forms. There is a growing concern regarding the safety of nanoparticles. This study aimed to evaluate the cell membrane lipoperoxidation (LPO) and DNA integrity in red EARTHWORM Lumbricus rubellus when exposed to artificial soil systems containing different concentration of zinc oxide nanoparticles (n-ZnO).Exposure to n-ZnO led to an increase in LPO content and DNA DAMAGE (in terms of halos) in EARTHWORM COELOMOCYTEs. We identified a positive strong correlation (r=+0.891, p<0.01) between LPO and DNA DAMAGE/halos. In summary, we show that n-ZnO is toxic to soil organisms and may imposed a sever OXIDATIVE STRESS/LPO leading to DNA DAMAGEs.

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APA: Copy

ARABI, MEHRAN, NAJAFI, NARGES, & JAFARZADEH SAMANI, HOMEYRA. (2013). EVALUATION OF DNA DAMAGE AND LIPOPEROXIDATION CONTENT IN RED EARTHWORM, LUMBRICUS RUBELLUS EXPOSED TO ZINC OXIDE NANOPARTICLES. JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES, 2(1), 27-31. SID. https://sid.ir/paper/188730/en

Vancouver: Copy

ARABI MEHRAN, NAJAFI NARGES, JAFARZADEH SAMANI HOMEYRA. EVALUATION OF DNA DAMAGE AND LIPOPEROXIDATION CONTENT IN RED EARTHWORM, LUMBRICUS RUBELLUS EXPOSED TO ZINC OXIDE NANOPARTICLES. JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES[Internet]. 2013;2(1):27-31. Available from: https://sid.ir/paper/188730/en

IEEE: Copy

MEHRAN ARABI, NARGES NAJAFI, and HOMEYRA JAFARZADEH SAMANI, “EVALUATION OF DNA DAMAGE AND LIPOPEROXIDATION CONTENT IN RED EARTHWORM, LUMBRICUS RUBELLUS EXPOSED TO ZINC OXIDE NANOPARTICLES,” JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES, vol. 2, no. 1, pp. 27–31, 2013, [Online]. Available: https://sid.ir/paper/188730/en

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