A STUDY OF NANOSILVER DERMAL TOXICITY IN MICE BALB/C

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ARABI MEHRAN; YARMOHAMADI SAMANI PARISA

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Journal: JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES Year:2013 | Volume:2 | Issue:1 Page(s): 33-37

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Title

A STUDY OF NANOSILVER DERMAL TOXICITY IN MICE BALB/C

Author(s)

ARABI MEHRAN | YARMOHAMADI SAMANI PARISA | Issue Writer Certificate

Keywords

NANOSILVERQ1

DERMAL TOXICITYQ1

CUTANEOUS INFLAMMATIONQ1

HEPATIC BIOMARKERSQ1

TGF-BETA1Q1

Abstract

As a result of growing applications of manufactured nanoparticles, there is an increasing concern about possible side effects of exposure to these materials on human and environment. NANOSILVER (n-Ag) has found wide use in medical applications including development of silver-based dressings and silver-coated medical devices. However, toxicity of these particles clue to their dermal use has not been fully identified. In this study, we analyzed the potential DERMAL TOXICITY of n-Ag bandage (100 mg/mL) over a period of 3 and 7 days in mice balb/c. Silver nitrate bandage (100 mg/mL) was applied in the positive control group. We found no cutaneous inflammatory responses such as erythemia and/or eschar for n-Ag. However, exposure to these nanoparticles resulted in considerable increase of hepatic necrosis biomarkers viz. ALT and AST. On the other hand, TGF-BETA1 levels, an anti-inflammatory biomarker was found to be decreased significantly in mice blood sera following use of n-Ag bandage. No mortality was observed in n-Ag treated groups. Also, differences between n-Ag treated groups and positive control in hepatic and anti-inflammatory biomarkers was found to be significant.Briefly, our results reveal that dermal application of n-Ag does not lead to any external changes and observable inflammatory responses in animal skin. However, it can alter the level of some biomarkers related to liver function in blood serum of samples.

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APA: Copy

ARABI, MEHRAN, & YARMOHAMADI SAMANI, PARISA. (2013). A STUDY OF NANOSILVER DERMAL TOXICITY IN MICE BALB/C. JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES, 2(1), 33-37. SID. https://sid.ir/paper/188731/en

Vancouver: Copy

ARABI MEHRAN, YARMOHAMADI SAMANI PARISA. A STUDY OF NANOSILVER DERMAL TOXICITY IN MICE BALB/C. JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES[Internet]. 2013;2(1):33-37. Available from: https://sid.ir/paper/188731/en

IEEE: Copy

MEHRAN ARABI, and PARISA YARMOHAMADI SAMANI, “A STUDY OF NANOSILVER DERMAL TOXICITY IN MICE BALB/C,” JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES, vol. 2, no. 1, pp. 33–37, 2013, [Online]. Available: https://sid.ir/paper/188731/en

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