EXTRACTIVE SPECTROPHOTOMETRIC DETERMINATION OF MICONAZOLE NITRATE IN PURE AND PHARMACEUTICAL PREPARATION

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ALIZADEH NINA; ANSARI REZA; KHALEDI REZAEE NASIBEH

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Paper Information

Journal: JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES Year:2012 | Volume:1 | Issue:4 Page(s): 45-52

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Title

EXTRACTIVE SPECTROPHOTOMETRIC DETERMINATION OF MICONAZOLE NITRATE IN PURE AND PHARMACEUTICAL PREPARATION

Author(s)

ALIZADEH NINA | ANSARI REZA | KHALEDI REZAEE NASIBEH | Issue Writer Certificate

Keywords

MICONAZOLE NITRATEQ1

EXTRACTIVE SPECTROPHOTOMETRYQ1

BROMOTHYMOL BLUEQ1

ION-PAIR COMPLEXQ1

Abstract

A simple extractive spectrophotometric method has been developed for the estimation of MICONAZOLE NITRATE in both pure and pharmaceutical preparation. The method is based on the formation of ION-PAIR COMPLEX of the drug with acidic dye BROMOTHYMOL BLUE (BTB) in acidic condition, followed by its extraction in organic solvent (chloroform). The absorbance was measured against the corresponding blank. The maximum absorbance was found at 434 nm. Linear calibration graph was obtained in the concentration range 1-35 mg ml-1. The method was validated statistically. Recovery studies gave satisfactory results indicating that none of common additives and excipients interfere the assay method. The proposed methods were found to be simple, accurate and reproducible and their performance in analysis of cream formulation was successfully examined.

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References

ECONAZOLE AND MICONAZOLE INHIBIT STEROIDOGENESIS AND DISRUPT STEROIDOGENIC ACUTE REGULATORY (STAR) PROTEIN EXPRESSION POST-TRANSCRIPTIONALLY

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APA: Copy

ALIZADEH, NINA, ANSARI, REZA, & KHALEDI REZAEE, NASIBEH. (2012). EXTRACTIVE SPECTROPHOTOMETRIC DETERMINATION OF MICONAZOLE NITRATE IN PURE AND PHARMACEUTICAL PREPARATION. JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES, 1(4), 45-52. SID. https://sid.ir/paper/188749/en

Vancouver: Copy

ALIZADEH NINA, ANSARI REZA, KHALEDI REZAEE NASIBEH. EXTRACTIVE SPECTROPHOTOMETRIC DETERMINATION OF MICONAZOLE NITRATE IN PURE AND PHARMACEUTICAL PREPARATION. JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES[Internet]. 2012;1(4):45-52. Available from: https://sid.ir/paper/188749/en

IEEE: Copy

NINA ALIZADEH, REZA ANSARI, and NASIBEH KHALEDI REZAEE, “EXTRACTIVE SPECTROPHOTOMETRIC DETERMINATION OF MICONAZOLE NITRATE IN PURE AND PHARMACEUTICAL PREPARATION,” JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES, vol. 1, no. 4, pp. 45–52, 2012, [Online]. Available: https://sid.ir/paper/188749/en

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