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Information Journal Paper

Title

EFFECT OF HYDROALCOHOLIC GRAPE SEED EXTRACT (VITIS VINIFERA L.) ON POLYCYSTIC OVARIAN SYNDROME IN FEMALE WISTAR RAT

Pages

  153-164

Abstract

 Aim: In this experimental study effect of grape seed extract on POLYCYSTIC OVARIAN SYNDROME (PCOS) in female Wistar rats, were assessed.Material and Methods: In this experimental study 30 rats were divided into 6 groups including control, the PCOS and four experimental groups. Four experimental groups were treated with intrapritoneal injection of grape seed extract (doses 50, 75, 100, 200 mg/kg for 10 days). Polycystic ovary was induced by subcutaneous injection of 2 mg ESTRADIOL VALERATE in adult rats. Ovaries of all groups were removed, fixed in Bouin’s fixative and 5 mm sections were stained using Hematoxylin–Eosin.Results: Results showed a significant decrease in the number of primordial, primary, preantral, Graafian follicles and corpus luteum in PCOS group with comparison with control (P<0.05). Measuring granulosa layer and theca thickness, various follicles diameters and their numbers showed much improvement in treated PCOS groups with HYDROALCOHOLIC GRAPE SEED EXTRACT. Fifty and seventy five mg/kg doses were considered as effective doses.Conclusion: According to this study results, it can be concluded that HYDROALCOHOLIC GRAPE SEED EXTRACT can improve the symptoms of POLYCYSTIC OVARIAN SYNDROME.

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    APA: Copy

    MOHSENI KOUCHESFAHANI, H., PARIVAR, K., & SALMABADI, Z.. (2015). EFFECT OF HYDROALCOHOLIC GRAPE SEED EXTRACT (VITIS VINIFERA L.) ON POLYCYSTIC OVARIAN SYNDROME IN FEMALE WISTAR RAT. JOURNAL OF CELL & TISSUE, 6(2), 153-164. SID. https://sid.ir/paper/188916/en

    Vancouver: Copy

    MOHSENI KOUCHESFAHANI H., PARIVAR K., SALMABADI Z.. EFFECT OF HYDROALCOHOLIC GRAPE SEED EXTRACT (VITIS VINIFERA L.) ON POLYCYSTIC OVARIAN SYNDROME IN FEMALE WISTAR RAT. JOURNAL OF CELL & TISSUE[Internet]. 2015;6(2):153-164. Available from: https://sid.ir/paper/188916/en

    IEEE: Copy

    H. MOHSENI KOUCHESFAHANI, K. PARIVAR, and Z. SALMABADI, “EFFECT OF HYDROALCOHOLIC GRAPE SEED EXTRACT (VITIS VINIFERA L.) ON POLYCYSTIC OVARIAN SYNDROME IN FEMALE WISTAR RAT,” JOURNAL OF CELL & TISSUE, vol. 6, no. 2, pp. 153–164, 2015, [Online]. Available: https://sid.ir/paper/188916/en

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