PROTECTIVE EFFECT OF NIGELLA SATIVA OIL ON THE BISPHENOL A INDUCED-TESTICULAR TOXICITY IN ADULT MICE (NMRI): A STEREOLOGICAL STUDY

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SOLEIMANI MEHRANJANI M.; SHARIATZADEH S.M.A.; AZADPOUR M.

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Journal: JOURNAL OF CELL & TISSUE Year:2015 | Volume:6 | Issue:1 Page(s): 87-96

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Title

PROTECTIVE EFFECT OF NIGELLA SATIVA OIL ON THE BISPHENOL A INDUCED-TESTICULAR TOXICITY IN ADULT MICE (NMRI): A STEREOLOGICAL STUDY

Author(s)

SOLEIMANI MEHRANJANI M. | SHARIATZADEH S.M.A. | AZADPOUR M. | Issue Writer Certificate

Keywords

STEREOLOGYQ2

BISPHENOL AQ2

TESTESQ2

NIGELLA SATIVA OILQ1

Abstract

Aim: The aim of this study was to investigate the protective effect of NIGELLA SATIVA OIL (NSO), as an antioxidant, on the testicular tissue in mice treated with BISPHENOL A.Material and Methods: In this study, 24 adult male mice NMRI were divided into four groups (n=6): control, BISPHENOL A (200 mg/kg/day), NIGELLA SATIVA OIL (5 ml/kg/day) and BISPHENOL A + NIGELLA SATIVA OIL. 34 days after oral treatment, the right testis was taken out, fixed and processed followed by Heidenhain’s Azan staining. The morphometric parameters of the testicular tissue were evaluated using stereological methods.Results: The mean volume of seminiferous tubules and it’s height of the germinal epithelium, the mean diameter and thickness of the basement membrane, the mean number of spermatocytes, round and long spermatids, spermatogonia and sertoli cells significantly reduced in the BISPHENOL A group compared to the controls (P<0.05). The mean volume of seminiferous tubules and the mean number of Sertoli cells significantly increased in the BISPHENOL A + NIGELLA SATIVA OIL group to the control level, The mean number of spermatocytes and round and long spermatids also showed a significant increase in this group compared to the BISPHENOL A group (P<0.05).Conclusion: Co-administration of NIGELLA SATIVA OIL with BISPHENOL A can prevent the adverse effects of BISPHENOL A on the testicular tissue in adult mice.

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APA: Copy

SOLEIMANI MEHRANJANI, M., SHARIATZADEH, S.M.A., & AZADPOUR, M.. (2015). PROTECTIVE EFFECT OF NIGELLA SATIVA OIL ON THE BISPHENOL A INDUCED-TESTICULAR TOXICITY IN ADULT MICE (NMRI): A STEREOLOGICAL STUDY. JOURNAL OF CELL & TISSUE, 6(1), 87-96. SID. https://sid.ir/paper/189012/en

Vancouver: Copy

SOLEIMANI MEHRANJANI M., SHARIATZADEH S.M.A., AZADPOUR M.. PROTECTIVE EFFECT OF NIGELLA SATIVA OIL ON THE BISPHENOL A INDUCED-TESTICULAR TOXICITY IN ADULT MICE (NMRI): A STEREOLOGICAL STUDY. JOURNAL OF CELL & TISSUE[Internet]. 2015;6(1):87-96. Available from: https://sid.ir/paper/189012/en

IEEE: Copy

M. SOLEIMANI MEHRANJANI, S.M.A. SHARIATZADEH, and M. AZADPOUR, “PROTECTIVE EFFECT OF NIGELLA SATIVA OIL ON THE BISPHENOL A INDUCED-TESTICULAR TOXICITY IN ADULT MICE (NMRI): A STEREOLOGICAL STUDY,” JOURNAL OF CELL & TISSUE, vol. 6, no. 1, pp. 87–96, 2015, [Online]. Available: https://sid.ir/paper/189012/en

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