GROWTH INHIBITION AND INDUCTION OF APOPTOSIS BY ETHER SOLUBLE METABOLITES OF STREPTOMYCES SP. ABRIINW 111 IN HUMAN MYELOID LEUKEMIA K562 CELL LINE

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MOOSAVI M.A.; GHANBARVAND F.; DEHNAD A.R.

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Journal: JOURNAL OF CELL & TISSUE Year:2011 | Volume:2 | Issue:3 Page(s): 225-234

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Information Journal Paper

Title

GROWTH INHIBITION AND INDUCTION OF APOPTOSIS BY ETHER SOLUBLE METABOLITES OF STREPTOMYCES SP. ABRIINW 111 IN HUMAN MYELOID LEUKEMIA K562 CELL LINE

Author(s)

MOOSAVI M.A. | GHANBARVAND F. | DEHNAD A.R. | Issue Writer Certificate

Keywords

APOPTOSISQ2

CHRONIC MYELOID LEUKEMIAQ2

NATURAL PRODUCTSQ2

STREPTOMYCESQ2

Abstract

Aim: Since induction of APOPTOSIS is an important strategy in cancer treatment, many attempts are in program to find new apoptotic inducer agents. Hence, ether soluble metabolites from Iranian native bacteria, STREPTOMYCES sp. ABRIINW 111, were isolated and anti-cancer activity of these metabolites was studied using human CHRONIC MYELOID LEUKEMIA K562 cells. Materials and methods: K562 cells were treated by various concentrations of these metabolites for 12- 72 h. Trypan blue exclusion test and DNA fragmentation assay were used to study growth inhibition and APOPTOSIS occurrence, respectively. Results: Ether soluble metabolites induced growth inhibition in K562 cells in a concentration- and time- dependent manner. IC50 values after 24 and 48 h treatment were 1000 and 400 ng/ml, respectively. Moreover, these metabolites caused significant decrease in K562 cells viability (P<0.05). Light microscopy and DNA fragmentation assay results showed APOPTOSIS induction in treated cell. Conclusion: According to APOPTOSIS deficient and drug resistance in cancer cells, identification of new APOPTOSIS inducers such as ether soluble metabolites could be helpful in more investigations in cancer treatment.

Cites

MOLECULAR IDENTIFICATION, ISOLATION AND EVALUATION OF PERSIAN GULF ACTINOMYCETES AS CANDIDATES OF CYTOTOXIC METABOLITES AGAINST BREAST CANCER

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APA: Copy

MOOSAVI, M.A., GHANBARVAND, F., & DEHNAD, A.R.. (2011). GROWTH INHIBITION AND INDUCTION OF APOPTOSIS BY ETHER SOLUBLE METABOLITES OF STREPTOMYCES SP. ABRIINW 111 IN HUMAN MYELOID LEUKEMIA K562 CELL LINE. JOURNAL OF CELL & TISSUE, 2(3), 225-234. SID. https://sid.ir/paper/189097/en

Vancouver: Copy

MOOSAVI M.A., GHANBARVAND F., DEHNAD A.R.. GROWTH INHIBITION AND INDUCTION OF APOPTOSIS BY ETHER SOLUBLE METABOLITES OF STREPTOMYCES SP. ABRIINW 111 IN HUMAN MYELOID LEUKEMIA K562 CELL LINE. JOURNAL OF CELL & TISSUE[Internet]. 2011;2(3):225-234. Available from: https://sid.ir/paper/189097/en

IEEE: Copy

M.A. MOOSAVI, F. GHANBARVAND, and A.R. DEHNAD, “GROWTH INHIBITION AND INDUCTION OF APOPTOSIS BY ETHER SOLUBLE METABOLITES OF STREPTOMYCES SP. ABRIINW 111 IN HUMAN MYELOID LEUKEMIA K562 CELL LINE,” JOURNAL OF CELL & TISSUE, vol. 2, no. 3, pp. 225–234, 2011, [Online]. Available: https://sid.ir/paper/189097/en

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