ASSESSMENT OF OXIDATIVE STRESS IN ACUTE MYELOID LEUKEMIA

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ESFAHANI ALI; GHOREISHI ZOHREH; NIKANFAR ALIREZA; SANAAT ZOHREH; GHORBANIHAGHJO AMIR; RASHTCHIZADEH NADEREH

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Title

ASSESSMENT OF OXIDATIVE STRESS IN ACUTE MYELOID LEUKEMIA

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Keywords

ACUTE MYELOID LEUKEMIAQ2

ANTIOXIDANTQ3

CYTARABINEQ3

DAUNORUBICINQ3

OXIDATIVE STRESSQ3

Abstract

Background: Many chemotherapeutic regimens used in the treatment of cancer generate free radicals that may be a part of their beneficial effects. The aim of this study was to assess the oxidative status in patients undergoing chemotherapy for ACUTE MYELOID LEUKEMIA (AML).Methods: Thirty-eight patients with AML (17 female and 21 male patients) with a mean age 34.05±12.49 years were included in the study. All the patients received CYTARABINE and DAUNORUBICIN as their standard induction therapy. Serum levels of malondialdehyde (MDA), total ANTIOXIDANT capacity (TAC), and also the erythrocyte superoxide dismutase and glutathione peroxidase activities were measured before and 14 days after chemotherapy.Results: Plasma malondialdehyde concentrations increased significantly (from a former 2.68±0.89 nmol/ml to 3.14±1.29 nmol/ml) 14 days post chemotherapy (p=0.04). Moreover, the total plasma ANTIOXIDANT capacity changed from 1.09±0.15 mmol/L to 1.02±0.14 mmol/L (p=0.005). Erythrocyte superoxide dismutase and glutathione peroxidase activity decreased over time from 1157.24±543.61 U/gHb to 984.01±419.09 U/gHb (p=0.04) and 46.96±13.70 U/gHb to 41.40±6.44 U/gHb (p=0.02), respectively.Conclusion: In this study, an increase in malondialdehyde levels and a decrease in the levels of ANTIOXIDANT enzymes and total ANTIOXIDANT capacity were observed. It seems that chemotherapy by CYTARABINE and DAUNORUBICIN generates enormous amounts of free radicals in patients undergoing the treatment for AML. Use of ANTIOXIDANT supplementation during chemotherapy i is discouraged as it may interfere with the generation of free radicals that may be a part of the therapeutic efficacy of these drugs.

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APA: Copy

ESFAHANI, ALI, GHOREISHI, ZOHREH, NIKANFAR, ALIREZA, SANAAT, ZOHREH, GHORBANIHAGHJO, AMIR, & RASHTCHIZADEH, NADEREH. (2011). ASSESSMENT OF OXIDATIVE STRESS IN ACUTE MYELOID LEUKEMIA. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 68(11), 649-654. SID. https://sid.ir/paper/38625/en

Vancouver: Copy

ESFAHANI ALI, GHOREISHI ZOHREH, NIKANFAR ALIREZA, SANAAT ZOHREH, GHORBANIHAGHJO AMIR, RASHTCHIZADEH NADEREH. ASSESSMENT OF OXIDATIVE STRESS IN ACUTE MYELOID LEUKEMIA. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2011;68(11):649-654. Available from: https://sid.ir/paper/38625/en

IEEE: Copy

ALI ESFAHANI, ZOHREH GHOREISHI, ALIREZA NIKANFAR, ZOHREH SANAAT, AMIR GHORBANIHAGHJO, and NADEREH RASHTCHIZADEH, “ASSESSMENT OF OXIDATIVE STRESS IN ACUTE MYELOID LEUKEMIA,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 68, no. 11, pp. 649–654, 2011, [Online]. Available: https://sid.ir/paper/38625/en

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