GROWTH INHIBITORY AND DIFFERENTIATING EFFECTS OF ETHYL ACETATE SOLUBLE METABOLITE OF IRANIAN NATIVE BACTERIA, STREPTOMYCES CALVUS, IN HUMAN MYELOID LEUKEMIA K562 CELL LINE

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MOUSAVI SEYED MOHAMMAD AMIN; GHANBARVAND FARIDEH; DEHNAD ALI REZA

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Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2012 | Volume:22 | Issue:3 (69) Page(s): 175-183

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Title

GROWTH INHIBITORY AND DIFFERENTIATING EFFECTS OF ETHYL ACETATE SOLUBLE METABOLITE OF IRANIAN NATIVE BACTERIA, STREPTOMYCES CALVUS, IN HUMAN MYELOID LEUKEMIA K562 CELL LINE

Author(s)

MOUSAVI SEYED MOHAMMAD AMIN | GHANBARVAND FARIDEH | DEHNAD ALI REZA | Issue Writer Certificate

Keywords

CHRONIC MYELOID LEUKEMIAQ2

DIFFERENTIATIONQ2

NATURAL PRODUCTSQ2

STREPTOMYCESQ2

Abstract

Background: Because drug resistance is one of the most important problems in patients with CHRONIC MYELOID LEUKEMIA (CML), finding new anti-cancer drugs especially from natural sources is research priority. Therefore, in this study, anti-cancer effects of ethyl acetate soluble metabolite of Iranian native bacteria, STREPTOMYCES calvus, were studied using human CHRONIC MYELOID LEUKEMIA K562 cells.Materials and methods: In this experimental trail, ethyl acetate soluble metabolites were isolated fromS. calvus bacteria. K562 cell line was treated by various concentrations of this metabolite for 12-72h intervals. Anti-proliferative effects of ethyl acetate soluble metabolite were studied by trypan blue exclusion test. Wright-Giemsa staining and latex particle phagocytosis assay were used to study differentiated cells.Results: Ethyl acetate soluble metabolite induced growth inhibition in K562 cells in concentration and time- dependent manner. At the concentration of 200 ng/ml, the growth was inhibited 19-50% after 12-72h. Latex particle phagocytosis assay and Wright- Giemsa staining results revealed that K562 cells were differentiated toward monocytic- macrophagic lineage.Conclusion: According to growth inhibitory and differentiating effects of S.calvus metabolite in K562 cells, this metabolite can be proposed for more investigations in DIFFERENTIATION therapy of CML patients.

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APA: Copy

MOUSAVI, SEYED MOHAMMAD AMIN, GHANBARVAND, FARIDEH, & DEHNAD, ALI REZA. (2012). GROWTH INHIBITORY AND DIFFERENTIATING EFFECTS OF ETHYL ACETATE SOLUBLE METABOLITE OF IRANIAN NATIVE BACTERIA, STREPTOMYCES CALVUS, IN HUMAN MYELOID LEUKEMIA K562 CELL LINE. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 22(3 (69)), 175-183. SID. https://sid.ir/paper/98635/en

Vancouver: Copy

MOUSAVI SEYED MOHAMMAD AMIN, GHANBARVAND FARIDEH, DEHNAD ALI REZA. GROWTH INHIBITORY AND DIFFERENTIATING EFFECTS OF ETHYL ACETATE SOLUBLE METABOLITE OF IRANIAN NATIVE BACTERIA, STREPTOMYCES CALVUS, IN HUMAN MYELOID LEUKEMIA K562 CELL LINE. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2012;22(3 (69)):175-183. Available from: https://sid.ir/paper/98635/en

IEEE: Copy

SEYED MOHAMMAD AMIN MOUSAVI, FARIDEH GHANBARVAND, and ALI REZA DEHNAD, “GROWTH INHIBITORY AND DIFFERENTIATING EFFECTS OF ETHYL ACETATE SOLUBLE METABOLITE OF IRANIAN NATIVE BACTERIA, STREPTOMYCES CALVUS, IN HUMAN MYELOID LEUKEMIA K562 CELL LINE,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 22, no. 3 (69), pp. 175–183, 2012, [Online]. Available: https://sid.ir/paper/98635/en

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