QUINOLONE RESISTANCE ASSOCIATED WITH EFLLUX PUMPS MEXAB-OPRM IN CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SALEHI MITRA; HEKMATDOOST MINA; HOSSEINI FARZANEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF MICROBIAL WORLD Year:2014 | Volume:6 | Issue:4 (17) Page(s): 290-298

Download Full-Text

Persian Verion

View:

1,099

Download:

Cites:

Information Journal Paper

Title

QUINOLONE RESISTANCE ASSOCIATED WITH EFLLUX PUMPS MEXAB-OPRM IN CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA

Author(s)

SALEHI MITRA | HEKMATDOOST MINA | HOSSEINI FARZANEH | Issue Writer Certificate

Keywords

PSEUDOMONAS AERUGINOSAQ2

MEXBQ2

QUINOLONE RESISTANCEQ2

MULTIDRUG EFLLUX PUMPSQ2

Abstract

Background and Objectives: PSEUDOMONAS AERUGINOSA is one of the most common antibiotic resistant bacteria and, therefore, treatments of Pseudomonad-caused infections are complicated. MexAB-OprM pump exports many antimicrobial compounds regardless of their structural and functional similarities. The MEXB gene encodes a proton-drug antiporter in MexAB-OprM pump. The present study was aimed to evaluate and detect the QUINOLONE RESISTANCE associated with efllux pumps mexAB-oprM in P. aeruginosa isolated from clinical specimens.Materials and Methods: This cross-sectional study was performed on 104 P. aeruginosa isolated from patients hospitalized in Trauma and Burn Intensive Care Unit (TBICU). The Genera and strains were identified primarily based on biochemical tests. The evaluation of antibiotic resistance pattern was carried out using disk diffusion method for 11 common antibiotics and microdilution broth method for 4 antibiotics. The presence of MEXB gene was investigated using PCR method.Results: According to the results, the most antibiotic resistance pattern were seen through treatment with nalidixic acid (86.54%), ceftazidime (82.2%) and ofloxacin (81.78%). Furthermore, the minimum antibiotic resistance were observed through treatment with imipenem (40.91%), piperacillin (44.9%) and tetracycline (48.03%). Based on MIC, the highest and lowest antibiotic sensitivity was recorded for tetracycline and ceftriaxone, respectively. Based on the PCR method, 27% of the clinical isolates harbor the mexAB-oprM operon.Conclusion: Based on the results, there is a significant association between presence of MEXB gene and mexAB-oprM pump and antibiotic resistance in P. aeruginosa. Regarding the importance of antibiotic resistance, the study of other efllux pumps, comparison of antibiotic resistance profile and the relationship between efllux pumps and clinical origin of the strains are recommended.

Cites

References

No record.

Cite

APA: Copy

SALEHI, MITRA, HEKMATDOOST, MINA, & HOSSEINI, FARZANEH. (2014). QUINOLONE RESISTANCE ASSOCIATED WITH EFLLUX PUMPS MEXAB-OPRM IN CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA. JOURNAL OF MICROBIAL WORLD, 6(4 (17)), 290-298. SID. https://sid.ir/paper/189303/en

Vancouver: Copy

SALEHI MITRA, HEKMATDOOST MINA, HOSSEINI FARZANEH. QUINOLONE RESISTANCE ASSOCIATED WITH EFLLUX PUMPS MEXAB-OPRM IN CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA. JOURNAL OF MICROBIAL WORLD[Internet]. 2014;6(4 (17)):290-298. Available from: https://sid.ir/paper/189303/en

IEEE: Copy

MITRA SALEHI, MINA HEKMATDOOST, and FARZANEH HOSSEINI, “QUINOLONE RESISTANCE ASSOCIATED WITH EFLLUX PUMPS MEXAB-OPRM IN CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA,” JOURNAL OF MICROBIAL WORLD, vol. 6, no. 4 (17), pp. 290–298, 2014, [Online]. Available: https://sid.ir/paper/189303/en

Related Journal Papers