FREQUENCY OF PLASMID-MEDIATED QUINOLONE RESISTANCE GENES AMONG CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA IN KERMAN, IRAN

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RAJAEI SOHRAB; Kazemi Pour Nadia; ROKHBAKHSH ZAMIN FAROKH

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Journal: IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY Year:2017 | Volume:11 | Issue:3 Page(s): 10-18

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Information Journal Paper

Title

FREQUENCY OF PLASMID-MEDIATED QUINOLONE RESISTANCE GENES AMONG CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA IN KERMAN, IRAN

Author(s)

RAJAEI SOHRAB | Kazemi Pour Nadia | ROKHBAKHSH ZAMIN FAROKH | Issue Writer Certificate

Keywords

PSEUDOMONAS AERUGINOSAQ2

PCRQ3

QNRQ2

AAC(6)-CRQ2

ANTIBIOTIC RESISTANCEQ2

Abstract

Background and Aims: plasmid genes are responsible for resistance to quinolones and fluoroquinolones, so the present study aims to identify the presence ofqnr and aac genes in clinical isolates ofP. aeruginosa.Materials and Methods: In 2016, 60 strains of P. aeruginosa were isolated from clinical specimens of patients in Kerman hospitals. ANTIBIOTIC RESISTANCE patterns were evaluated using Kirby-Bauer and micro dilution methods against 10 antibiotics according to CLSI criteria Specific primers and polymerase chain reaction were used to detect and amplifyqnr and aac (6) -Ib-cr genes.Results: Maximum ANTIBIOTIC RESISTANCE was observed against cefexim (80%) and calidixic acid (75%) and minimum resistance against imipenem (25%) and ciprofloxacin (35%). The incidence rate of quinolone resistance genes were as follows: QNR A (16.66%), QNRB (13.33%), QNRS(11.66%) and aac (6) -Ib-cr (8.33%).Conclusions: In the present study, QNRA gene had the highest incidence rates among the studied genes. Because of the importance of ANTIBIOTIC RESISTANCE and the high prevalence ofqnr genes found in this study, furthur studies need to be carried out onqnr resistance genes in the regional and national dimension.

Cites

The Study of Frequency of SIM and AmpC Genes in Clinical Isolates of Pseudomonas aeruginosa in Gilan, Iran

References

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APA: Copy

RAJAEI, SOHRAB, Kazemi Pour, Nadia, & ROKHBAKHSH ZAMIN, FAROKH. (2017). FREQUENCY OF PLASMID-MEDIATED QUINOLONE RESISTANCE GENES AMONG CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA IN KERMAN, IRAN. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, 11(3), 10-18. SID. https://sid.ir/paper/132655/en

Vancouver: Copy

RAJAEI SOHRAB, Kazemi Pour Nadia, ROKHBAKHSH ZAMIN FAROKH. FREQUENCY OF PLASMID-MEDIATED QUINOLONE RESISTANCE GENES AMONG CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA IN KERMAN, IRAN. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY[Internet]. 2017;11(3):10-18. Available from: https://sid.ir/paper/132655/en

IEEE: Copy

SOHRAB RAJAEI, Nadia Kazemi Pour, and FAROKH ROKHBAKHSH ZAMIN, “FREQUENCY OF PLASMID-MEDIATED QUINOLONE RESISTANCE GENES AMONG CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA IN KERMAN, IRAN,” IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, vol. 11, no. 3, pp. 10–18, 2017, [Online]. Available: https://sid.ir/paper/132655/en

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