DETERMINATION OF ANTIBIOTIC RESISTANCE PATTERN AND FREQUENCY OF BLAVIM & BLAIMP GENES IN CLINICAL ISOLATES OF ACINETOBACTER SPECIES IN BANDAR ABBASS

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GOLESTANI FAHIME; JAVADPOUR SEDIGHEH; KAFILZADEH FARSHID; GHALANDARZADEH DARYAEI ZEINAB

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Journal: JOURNAL OF MICROBIAL WORLD Year:2018 | Volume:10 | Issue:4 (33) Page(s): 299-309

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Title

DETERMINATION OF ANTIBIOTIC RESISTANCE PATTERN AND FREQUENCY OF BLAVIM & BLAIMP GENES IN CLINICAL ISOLATES OF ACINETOBACTER SPECIES IN BANDAR ABBASS

Author(s)

GOLESTANI FAHIME | JAVADPOUR SEDIGHEH | KAFILZADEH FARSHID | GHALANDARZADEH DARYAEI ZEINAB | Issue Writer Certificate

Keywords

ACINETOBACTER BAUMANNIIQ1

METALO-BETALACTAMASEQ2

IMIPENEMQ1

MEROPENEMQ1

BLAIMP GENEQ1

BLAVIM GENEQ1

Abstract

Background & Objectives: Acinetobacter spp. are non-fermenting Gram-negative bacteria that are associated with nosocomial infections. They are serious opportunistic pathogens with resistance to many antibiotics due to the presence of Metallo-beta-lactamase (MBL) genes. The aims of this study were to determine antimicrobial susceptibility and frequency of MBLs genes in clinical isolates of Acinetobacter species in Shahid Mohammadi hospital, Bandar Abbas, Iran. Material & Methods: This descriptive-cross-sectional study was carried out on 81 Acinetobacter isolates collected from different clinical samples from Shahid Mohammadi hospital, Bandar Abbas, Iran. The bacteria were identified to the species level by Microgen GNA-ID System kit. The Kirby-Bauer disk diffusion test was used to determine antibiotic resistance pattern. MIC of MEROPENEM was determined by E-test, and MBLs production was detected by IMIPENEM-EDTA synergy test (CDST method). The isolates were then subjected to polymerase chain reaction (PCR) for detection of blaIMP and BLAVIM GENEs. Results: Out of 81 isolates, 79(97. 54%) were identified as A. baumanni, 1 (1. 23%) as A. lwoffii and 1(1. 23%) as A. haemolyticus. Acinetobacter spp. showed the highest resistance to IMIPENEM and MEROPENEM (81. 5%) and the highest susceptibility to polymyxin B (96. 3%) and colistin(95. 1%), respectively. MIC determination by E-test revealed 77. 8% of isolates as MEROPENEM-resistant. 76. 5% of isolates were identified as MBL-positive by CDST method. Also, 13 (16%) isolates carried BLAIMP GENE, but none of them had the BLAVIM GENE. Conclusion: Dissemination of MBL-producing A. baumannii is worrisome. In order to reduce and control Acinetobacter infections, implementation of strict surveillance, and judicious prescribing of antibiotics is necessary.

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APA: Copy

GOLESTANI, FAHIME, JAVADPOUR, SEDIGHEH, KAFILZADEH, FARSHID, & GHALANDARZADEH DARYAEI, ZEINAB. (2018). DETERMINATION OF ANTIBIOTIC RESISTANCE PATTERN AND FREQUENCY OF BLAVIM & BLAIMP GENES IN CLINICAL ISOLATES OF ACINETOBACTER SPECIES IN BANDAR ABBASS. JOURNAL OF MICROBIAL WORLD, 10(4 (33) ), 299-309. SID. https://sid.ir/paper/189311/en

Vancouver: Copy

GOLESTANI FAHIME, JAVADPOUR SEDIGHEH, KAFILZADEH FARSHID, GHALANDARZADEH DARYAEI ZEINAB. DETERMINATION OF ANTIBIOTIC RESISTANCE PATTERN AND FREQUENCY OF BLAVIM & BLAIMP GENES IN CLINICAL ISOLATES OF ACINETOBACTER SPECIES IN BANDAR ABBASS. JOURNAL OF MICROBIAL WORLD[Internet]. 2018;10(4 (33) ):299-309. Available from: https://sid.ir/paper/189311/en

IEEE: Copy

FAHIME GOLESTANI, SEDIGHEH JAVADPOUR, FARSHID KAFILZADEH, and ZEINAB GHALANDARZADEH DARYAEI, “DETERMINATION OF ANTIBIOTIC RESISTANCE PATTERN AND FREQUENCY OF BLAVIM & BLAIMP GENES IN CLINICAL ISOLATES OF ACINETOBACTER SPECIES IN BANDAR ABBASS,” JOURNAL OF MICROBIAL WORLD, vol. 10, no. 4 (33) , pp. 299–309, 2018, [Online]. Available: https://sid.ir/paper/189311/en

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