RELATIVE QUANTITATION OF HYPHAE-SPECIFIC GENEHWP1 EXPRESSION IN INHIBITION OF CANDIDA ALBICANS BIOFILM

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KHODAVANDI ALIREZA; ALIZADEH FAHIMEH; SHAHINIPOR MOZHDEH

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Journal: JOURNAL OF MICROBIAL WORLD Year:2016 | Volume:9 | Issue:1 (26) Page(s): 22-33

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Title

RELATIVE QUANTITATION OF HYPHAE-SPECIFIC GENEHWP1 EXPRESSION IN INHIBITION OF CANDIDA ALBICANS BIOFILM

Author(s)

KHODAVANDI ALIREZA | ALIZADEH FAHIMEH | SHAHINIPOR MOZHDEH | Issue Writer Certificate

Keywords

BIOFILMQ2

LAMIACEAEQ1

HWP1 GENEQ1

CANDIDA ALBICANSQ1

Abstract

Background & Objectives: The incidence of candidiasis has been increased in immune compromised patients. BIOFILM formation is counted as the main mechanisms of antibiotic resistance in CANDIDA ALBICANS. The aim of this study was to investigate the effects extractions of LAMIACEAE family in quantification of HWP1 GENE expression responsible for inhibition of BIOFILM formation in C. albicans.Materials & Methods: In this cross- sectional study, the antifungal effect of aqueous and ethanolic extractions of leaf, stem and root of Mentha spicata, Mentha pulegium and Thymus vulgar, commercially purchased from Yasooj, was analyzed against C. albicans using disc diffusion and broth microdilution methods. The crystal violet colorimetric method, morphological response and expression pattern of hypha-specific gene HWP1 were carried out to investigate the BIOFILM-inhibitory properties of the best plant extract tested.Results: The data indicated that aqueous root extracts of Thymus vulgaris exhibits high antifungal activity against C. albicans. The aqueous extract of Thymus vulgaris root-treated cells exhibited significant reduction in BIOFILM growth. In addition, morphological observation of extract of Thymus vulgaris and fluconazole-treated cells confirmed decreases in fungal reproduction. Finally, aqueous root extractions of Thymus vulgaris was shown to down-regulate the expression of HWP1.Conclusion: The results of this study showed the possible molecular mechanism of effects of aqueous root extraction of Thymus vulgaris root in C. albicans on BIOFILM formation.

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APA: Copy

KHODAVANDI, ALIREZA, ALIZADEH, FAHIMEH, & SHAHINIPOR, MOZHDEH. (2016). RELATIVE QUANTITATION OF HYPHAE-SPECIFIC GENEHWP1 EXPRESSION IN INHIBITION OF CANDIDA ALBICANS BIOFILM. JOURNAL OF MICROBIAL WORLD, 9(1 (26)), 22-33. SID. https://sid.ir/paper/189341/en

Vancouver: Copy

KHODAVANDI ALIREZA, ALIZADEH FAHIMEH, SHAHINIPOR MOZHDEH. RELATIVE QUANTITATION OF HYPHAE-SPECIFIC GENEHWP1 EXPRESSION IN INHIBITION OF CANDIDA ALBICANS BIOFILM. JOURNAL OF MICROBIAL WORLD[Internet]. 2016;9(1 (26)):22-33. Available from: https://sid.ir/paper/189341/en

IEEE: Copy

ALIREZA KHODAVANDI, FAHIMEH ALIZADEH, and MOZHDEH SHAHINIPOR, “RELATIVE QUANTITATION OF HYPHAE-SPECIFIC GENEHWP1 EXPRESSION IN INHIBITION OF CANDIDA ALBICANS BIOFILM,” JOURNAL OF MICROBIAL WORLD, vol. 9, no. 1 (26), pp. 22–33, 2016, [Online]. Available: https://sid.ir/paper/189341/en

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