Study and detection of ERG11 gene mutation in resistant-drug Candida albicans and relation with Iranian women infertility

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SIASI ELHAM; Abdi barzegar Mohaddeseh; SOHRABVAND FARNAZ

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2019 | Volume:9 | Issue:34 Page(s): 83-92

Download Full-Text

Persian Verion

View:

393

Download:

Cites:

Information Journal Paper

Title

Study and detection of ERG11 gene mutation in resistant-drug Candida albicans and relation with Iranian women infertility

Author(s)

SIASI ELHAM | Abdi barzegar Mohaddeseh | SOHRABVAND FARNAZ | Issue Writer Certificate

Keywords

Candida albicansQ1

ERG11 geneQ1

InfertilityQ2

Abstract

Aim and Background: Candida albicans is the most important cause of vulvovaginal candidiasis and resistance to azoles can occur via various mechanisms including, change in the ERG11 gene. This study aim was to identification of ERG11 gene mutations in drug resistant Candida albicans isolated from patients with Candida vaginitis and its association with Infertility in Iranian women. Material and methods: From 100 patients with vaginitis Candida albicans species were isolated by using chromogen agar culture. The drug sensitivity was determined with standard protocol, diffusion disc test. Then extraction genome from resistance species and was used PCR and sequencing for investigation of ERG11 gene mutations. For detection of sperm parameters disorders and relation with Infertility, normal sperm was placed adjacent to sensitive and resistance Candida albicans by different concentrations and times. Results: From 100 patients, 40 samples of Candida albicans were isolated that 2 samples were fluconazole and ketoconazole-resistant. ERG11 gene mutations e in 2 samples were, conversion and insertion. In 10000 and 100000 CFU/ml concentrations, 4 hours and with 3 repeated, was observed significant relation to agglutination and reduction in motility of the sperms (P<0. 05). Conclusion: This study results showed that antibiotic resistance can be increased in Candida albicans with mutation in the ERG11 gene and this Candida vaginitis infections, can associated with Infertility in women.

Cites

No record.

References

No record.

Cite

APA: Copy

SIASI, ELHAM, Abdi barzegar, Mohaddeseh, & SOHRABVAND, FARNAZ. (2019). Study and detection of ERG11 gene mutation in resistant-drug Candida albicans and relation with Iranian women infertility. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 9(34 ), 83-92. SID. https://sid.ir/paper/204718/en

Vancouver: Copy

SIASI ELHAM, Abdi barzegar Mohaddeseh, SOHRABVAND FARNAZ. Study and detection of ERG11 gene mutation in resistant-drug Candida albicans and relation with Iranian women infertility. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2019;9(34 ):83-92. Available from: https://sid.ir/paper/204718/en

IEEE: Copy

ELHAM SIASI, Mohaddeseh Abdi barzegar, and FARNAZ SOHRABVAND, “Study and detection of ERG11 gene mutation in resistant-drug Candida albicans and relation with Iranian women infertility,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 9, no. 34 , pp. 83–92, 2019, [Online]. Available: https://sid.ir/paper/204718/en

Related Journal Papers