INTERACTIONS BETWEEN D1 DOPAMINERGIC SYSTEMS OF NUCLEUS ACCUMBENS SHELL AND GLUTAMATERGIC SYSTEM OF PRELIMBIC ON ANXIETY- LIKE BEHAVIORS OF WISTAR MALE RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AHMADI H.; ROSTAMI P.; ZARRINDAST M.R.; NASEHI M.; MOHSENI KOKHESFAHANI H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES) Year:2015 | Volume:8 | Issue:2 (29) Page(s): 59-74

Download Full-Text

Persian Verion

View:

980

Download:

Cites:

Information Journal Paper

Title

INTERACTIONS BETWEEN D1 DOPAMINERGIC SYSTEMS OF NUCLEUS ACCUMBENS SHELL AND GLUTAMATERGIC SYSTEM OF PRELIMBIC ON ANXIETY- LIKE BEHAVIORS OF WISTAR MALE RATS

Author(s)

Keywords

ACCUMBENS SHELLQ2

PRELIMBICQ2

ANXIETY-LIKE BEHAVIORSQ2

DOPAMINERGIC SYSTEMQ2

GLUTAMATERGIC SYSTEMQ2

Abstract

Inroduction & Objective: Nucleus accumbens (NAC), prefrontal cortex (PFC) dopaminergic and GLUTAMATERGIC SYSTEMs are involved in regulating anxiety- like behaviors, whileNAc DOPAMINERGIC SYSTEM activity is mediated by glutamatergic projections, via PFC.This study has investigated the involvement of NAc shell D1 dopaminergic and PRELIMBIC GLUTAMATERGIC SYSTEMs on anxiety- like behaviors.Material and Methods: Elevated plus-maze apparatus was employed to test parameters of ANXIETY-LIKE BEHAVIORS After 5 days surgery of male Wistar rats in a stereotaxic frame, Elevated plus-maze apparatus was employed for measuring parameters of ANXIETY-LIKE BEHAVIORS due to intrabrain injection of drugsSKF38393 (dopamine D1 receptor agonist), SCH23390 (dopamine D1 receptor antagonist), NMDA (receptor antagonist), D-AP7 (NMDA receptor antagonist) onWistarmale rats.Results: Unilateral intra- PRELIMBIC injection of NMDA (0.9 mg/ml), induced anxiolytic-like behaviors which has been blocked by D-AP7 (NMDA receptor antagonist, 0.25, 0.5 and 1 mg/ml). Moreover, unilateral infusion of SKF38393 (dopamine D1 receptor agonist, 3 mg/ml) 0.25, 0.5 and 1mg/ml) into the left NAc shell induced anxiolytic-like behaviors which was blocked by SCH23390 (0.25mg/ml), while, SCH23390 (dopamine D1 receptor antagonistdid not so; Furthermore, intra-NAc shell administration of subthreshold dose of SKF38393 (1 mg/ml) potentiated the lower dose, whereas decreased the higher dose of intra-left PRELIMBIC NMDA response. In addition, the subthreshold dose infusion of SCH23390 (0.25 mg/ml) into the left NAc shell, intra- PRELIMBIC NMDA reduced induced anxiolytic-like behaviors.Conclusion: The results demonstrated a modulatory effect of NAC shell D1 DOPAMINERGIC SYSTEM on anxiolyticlike response by injection in PRELIMBIC NMDA.

Cites

No record.

References

No record.

Cite

APA: Copy

AHMADI, H., ROSTAMI, P., ZARRINDAST, M.R., NASEHI, M., & MOHSENI KOKHESFAHANI, H.. (2015). INTERACTIONS BETWEEN D1 DOPAMINERGIC SYSTEMS OF NUCLEUS ACCUMBENS SHELL AND GLUTAMATERGIC SYSTEM OF PRELIMBIC ON ANXIETY- LIKE BEHAVIORS OF WISTAR MALE RATS. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), 8(2 (29)), 59-74. SID. https://sid.ir/paper/191587/en

Vancouver: Copy

AHMADI H., ROSTAMI P., ZARRINDAST M.R., NASEHI M., MOHSENI KOKHESFAHANI H.. INTERACTIONS BETWEEN D1 DOPAMINERGIC SYSTEMS OF NUCLEUS ACCUMBENS SHELL AND GLUTAMATERGIC SYSTEM OF PRELIMBIC ON ANXIETY- LIKE BEHAVIORS OF WISTAR MALE RATS. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES)[Internet]. 2015;8(2 (29)):59-74. Available from: https://sid.ir/paper/191587/en

IEEE: Copy

H. AHMADI, P. ROSTAMI, M.R. ZARRINDAST, M. NASEHI, and H. MOHSENI KOKHESFAHANI, “INTERACTIONS BETWEEN D1 DOPAMINERGIC SYSTEMS OF NUCLEUS ACCUMBENS SHELL AND GLUTAMATERGIC SYSTEM OF PRELIMBIC ON ANXIETY- LIKE BEHAVIORS OF WISTAR MALE RATS,” JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), vol. 8, no. 2 (29), pp. 59–74, 2015, [Online]. Available: https://sid.ir/paper/191587/en

Related Journal Papers