The effect of D2 dopaminergic system in nucleus accumbens and glutamatergic system of prelimbic area on anxiety-like behaviors in Wistar male rats

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AHMADI HATAM; ROSTAMI PARVIN; ZARRINDAST MOHAMMAD REZA; NASEHI MOHAMMAD

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Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2019 | Volume:41 | Issue:2 Page(s): 7-13

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Title

The effect of D2 dopaminergic system in nucleus accumbens and glutamatergic system of prelimbic area on anxiety-like behaviors in Wistar male rats

Author(s)

AHMADI HATAM | ROSTAMI PARVIN | ZARRINDAST MOHAMMAD REZA | NASEHI MOHAMMAD | Issue Writer Certificate

Keywords

Nucleus accumbensQ3

Prefrontal cortexQ1

AnxietyQ2

Dopaminergic systemQ1

Glutamatergic systemQ1

Abstract

Background: Neutrustransmitter systems of dopaminergic and glutamatergic of the Prefrontal cortex (PFC) and Nucleus accumbens (NAc) are involved in the regulation of Anxiety-like behaviors. In addition, the activity of the NAc Dopaminergic system is mediated by the glutamatergic inputs, which is mainly from the PFC. This study investigated the role of D2 Dopaminergic system in Nucleus accumbens and glutamatergical system of prelimbic area on Anxiety-like behaviors in male rats. Methods: This study was performed on four experimental groups in 35 groups of 8 male rats. after 5 days of surgery in a stereotaxic frame, the Elevated Plus maze apparatus was employed for the recording parameters of Anxiety-like behaviors due to intr-abrain injection of quinpirole (Dopamine receptor agonist), sulpiride (Dopaminergic D2 receptor antagonist), NMDA(NMDA receptor agonist) and D-AP7 (NMDA receptor antagonist. Results: Unilateral intra-left prelimbic injection of NMDA (0. 9 μ g/μ l) reduced the Anxiety-like behaviors (P<0. 01), which was blocked by D-AP7 injection (P<0. 01). Also, unilateral infusion of sulpiride (0. 4 and 0. 6 μ g/μ l) into the NAc shell induced anxiolytic-like behaviors (P<0. 05). Furthermore, the administration of the sub threshold dose of sulpiride (0. 2 μ g/μ l) in the NAc shell strengthened the effect of low dose NMDA (P<0. 05), whereas reduced its high dose (P<0. 01) in prelimbic. Conclusion: The results indicate the regulatory effect of the dopamine D2 system of NAc shell on the anxiolyticlike response caused by NMDA injection in prelimbic region.

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References

D1-like dopamine receptor dysfunction in the lateral habenula nucleus increased anxiety-like behavior in rat

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APA: Copy

AHMADI, HATAM, ROSTAMI, PARVIN, ZARRINDAST, MOHAMMAD REZA, & NASEHI, MOHAMMAD. (2019). The effect of D2 dopaminergic system in nucleus accumbens and glutamatergic system of prelimbic area on anxiety-like behaviors in Wistar male rats. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 41(2 ), 7-13. SID. https://sid.ir/paper/364656/en

Vancouver: Copy

AHMADI HATAM, ROSTAMI PARVIN, ZARRINDAST MOHAMMAD REZA, NASEHI MOHAMMAD. The effect of D2 dopaminergic system in nucleus accumbens and glutamatergic system of prelimbic area on anxiety-like behaviors in Wistar male rats. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;41(2 ):7-13. Available from: https://sid.ir/paper/364656/en

IEEE: Copy

HATAM AHMADI, PARVIN ROSTAMI, MOHAMMAD REZA ZARRINDAST, and MOHAMMAD NASEHI, “The effect of D2 dopaminergic system in nucleus accumbens and glutamatergic system of prelimbic area on anxiety-like behaviors in Wistar male rats,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 41, no. 2 , pp. 7–13, 2019, [Online]. Available: https://sid.ir/paper/364656/en

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