THE PATTERN OF EXPRESSION OF TUMOR NECROSIS FACTOR-Α INDUCEDBY HYDRO-ALCOHOLIC EXTRACT OF ZINGIBER OFFICINALE

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SAHRAEIAN Z.

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Journal: JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES) Year:2018 | Volume:11 | Issue:3 (42) Page(s): 41-53

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Title

THE PATTERN OF EXPRESSION OF TUMOR NECROSIS FACTOR-Α INDUCEDBY HYDRO-ALCOHOLIC EXTRACT OF ZINGIBER OFFICINALE

Author(s)

SAHRAEIAN Z. | Issue Writer Certificate

Keywords

ZINGIBER OFFICINALEQ2

TUMOR NECROSIS FACTOR-ALPHAQ1

MESENCHYMAL STEM CELLSQ2

DIABETES MELLITUSQ2

Abstract

Inroduction & Objective: Diabetes is known as an inflammatory disease associated with metabolicdisturbances. TUMOR NECROSIS FACTOR-ALPHA is one of the main inflammatory cytokines and plays a centralrole in host defense, inflammation and immune function. The use of various medicinal herbs, includingginger, has been used to reduce the complications of inflammation from the past. In this study, the effects ofvarious concentrations of ginger hydro-alcoholic extract on TNF-α gene expression in bone marrow derivedmesenchymal stem cells were investigated. Material and Methods: MESENCHYMAL STEM CELLS were studied in control group and six groups oftreatment with ginger hydro-alcoholic extract at concentrations of 100 and 50 μ g / ml at 2, 16 and 24 hours. mRNA of cells were extracted and after cDNA synthesis, TNF-α gene expression was investigated using qReal Time PCR. Using the expression level, the results were evaluated by t-test. Results: Samples treated with ginger extract at a concentration of 100 and 50 μ g / ml for 24 and 16 hoursshowed a significant decrease for TNF-α gene (p <0. 05) and there were no significant increase in othergroups. Conclusion: According to the results, this decrease in the expression of TNF-α indicates the long-termeffect of this extract compared to its short-term effect of 2 hour. Therefore, the effect of ginger on theexpression of TNF-α inflammatory gene is dependent on treatment concentration and time.

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APA: Copy

SAHRAEIAN, Z.. (2018). THE PATTERN OF EXPRESSION OF TUMOR NECROSIS FACTOR-Α INDUCEDBY HYDRO-ALCOHOLIC EXTRACT OF ZINGIBER OFFICINALE. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), 11(3 (42) ), 41-53. SID. https://sid.ir/paper/191730/en

Vancouver: Copy

SAHRAEIAN Z.. THE PATTERN OF EXPRESSION OF TUMOR NECROSIS FACTOR-Α INDUCEDBY HYDRO-ALCOHOLIC EXTRACT OF ZINGIBER OFFICINALE. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES)[Internet]. 2018;11(3 (42) ):41-53. Available from: https://sid.ir/paper/191730/en

IEEE: Copy

Z. SAHRAEIAN, “THE PATTERN OF EXPRESSION OF TUMOR NECROSIS FACTOR-Α INDUCEDBY HYDRO-ALCOHOLIC EXTRACT OF ZINGIBER OFFICINALE,” JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), vol. 11, no. 3 (42) , pp. 41–53, 2018, [Online]. Available: https://sid.ir/paper/191730/en

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