THE EFFECT OF SWIMMING EXERCISE ON MATRIX METALLOPROTEINASE 2 ACTIVITY AND TUMOR NECROSIS FACTOR-α LEVEL OF LIVER TISSUE IN ALLOXANINDUCED DIABETIC RATS

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HABIBIAN MASOUMEH; AMANIAN ANICEH

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Journal: DANESHVAR MEDICINE Year:2018 | Volume:25 | Issue:133 Page(s): 11-18

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Title

THE EFFECT OF SWIMMING EXERCISE ON MATRIX METALLOPROTEINASE 2 ACTIVITY AND TUMOR NECROSIS FACTOR-α LEVEL OF LIVER TISSUE IN ALLOXANINDUCED DIABETIC RATS

Author(s)

HABIBIAN MASOUMEH | AMANIAN ANICEH | Issue Writer Certificate

Keywords

DIABETES MELLITUSQ2

MATRIX METALLOPROTEINASE 2Q1

EXERCISEQ1

TUMOR NECROSIS FACTOR--αQ1

Abstract

Background and Objective: liver disease is highly prevalent in type 2 DIABETES MELLITUS (T2DM) and EXERCISE training is effective in preventing and treating diabetes-induced hepatic injury. Therefore, the aim of this study was to assess the effect of chronic swimming EXERCISE on the hepatic MATRIX METALLOPROTEINASE 2 (MMP-2) activity and tumor necrosis factor-a (TNF-a) level of liver tissue in alloxan-induced diabetic rats.Materials and Methods: In this study, 28 male Wistar rats were randomly divided into 4 groups (7 rats per group) of control, diabetes, EXERCISE, and diabetes-exercise. Diabetes was induced by alloxan (90 mg/kg, i.p.). The animals EXERCISEd by swimming training at 5 min to 30 min per day, five days a week over 8 weeks. The rats were killed 48 h after the last treatments and liver MMP-2 and TNF-a level were evaluated by zymography and ELISA methods.One-way analysis of variance was used for data analysis.Results: Findings showed that the diabetes significantly increases MMP-2 activity and TNF-a level in animals (p˂0.05). In addition, 8 weeks swimming training were associated with a significant decrease of TNF-a level and MMP-2 activity in the liver tissue of diabetic rats (p˂0.05).Conclusion: It seems that regular swimming training can partially prevent diabetes-induced liver injury via decreasing MMP-2 activity and TNF-a level in diabetic rats.

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References

THE EFFECT OF REGULAR SWIMMING EXERCISE ON THE LEVELS OF RENAL MATRIX METTALOPROTEINASE-2 AND TRANSFORMING GROWTH FACTOR-β1 IN RATS WITH DIABETES

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APA: Copy

HABIBIAN, MASOUMEH, & AMANIAN, ANICEH. (2018). THE EFFECT OF SWIMMING EXERCISE ON MATRIX METALLOPROTEINASE 2 ACTIVITY AND TUMOR NECROSIS FACTOR-α LEVEL OF LIVER TISSUE IN ALLOXANINDUCED DIABETIC RATS. DANESHVAR MEDICINE, 25(133 ), 11-18. SID. https://sid.ir/paper/30438/en

Vancouver: Copy

HABIBIAN MASOUMEH, AMANIAN ANICEH. THE EFFECT OF SWIMMING EXERCISE ON MATRIX METALLOPROTEINASE 2 ACTIVITY AND TUMOR NECROSIS FACTOR-α LEVEL OF LIVER TISSUE IN ALLOXANINDUCED DIABETIC RATS. DANESHVAR MEDICINE[Internet]. 2018;25(133 ):11-18. Available from: https://sid.ir/paper/30438/en

IEEE: Copy

MASOUMEH HABIBIAN, and ANICEH AMANIAN, “THE EFFECT OF SWIMMING EXERCISE ON MATRIX METALLOPROTEINASE 2 ACTIVITY AND TUMOR NECROSIS FACTOR-α LEVEL OF LIVER TISSUE IN ALLOXANINDUCED DIABETIC RATS,” DANESHVAR MEDICINE, vol. 25, no. 133 , pp. 11–18, 2018, [Online]. Available: https://sid.ir/paper/30438/en

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