THE EFFECTS OF TOPIRAMATE ANTIEPILEPTIC DRUG ON FETUS MALFORMATIONS IN NMRIMOUSE

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EBRAHIMI VERKIYANI M.; SHIRAVI A.; HOJATI V.

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Journal: JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES) Year:2018 | Volume:11 | Issue:3 (42) Page(s): 67-76

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Title

THE EFFECTS OF TOPIRAMATE ANTIEPILEPTIC DRUG ON FETUS MALFORMATIONS IN NMRIMOUSE

Author(s)

EBRAHIMI VERKIYANI M. | SHIRAVI A. | HOJATI V. | Issue Writer Certificate

Keywords

TOPIRAMATE‚Q1

TERATOGENIC‚Q2

FETAL‚Q1

MOUSEQ2

Abstract

Inroduction & Objective: One of the most important complications of utilization of anti epilepcy drugs inpregnancy is increase of fetal abnormality. There are not enough information about teratogenic effects oftopiramateon pregnancy on the fetal organogenesis. Hence‚ this study was designed to determine the macroscopicabnormalities created by topiramate during organogenesis of MOUSEfetus. Material and Method: In this study forty white small experimental mice (NMRI type) were divided in tothree experimental groups (Ι , Π ‚ III) and one control group. Three experimental groups received respectively50, 100 and 200 ml/kg/day of topiramateand the control group received normal saline with 0. 2 cc volume from theday 6 (GD6) to day 14 (GD14) of pregnancy intraperitoneally (ip). The mice on the eighteen day of pregnancy weresacrifieed and fetus were studied after determination of the mean wight and crown-rump legth‚ were examinedmacroscopically. data were analyzed by using SPSSstatistical software and ANOVA and LSDtests. Results: : In average weight in experimental group Ш compared with the control groups was seen asignificantly reduction (P 0. 05). In the experimental groupsof Π and Ш the average crown-rump legth of fetuswas significantly reduced compared with the control group(P 0. 05). A significant increase Was seenin theincidence of hemorrhage and fetal resorption in the experimental group of Ι ‚ Π and Ш compared with thecontrol(P 0. 05). In three experimental groupsthe number of fetus was significantly reduced compared with thecontrol group(P 0. 05). Conclusion: The utilization of topiramatein MOUSE during organogenesis stages is caused weight, crownrumpandnumber of fetusesreducation; too is caused fetal absorption andhemorrhage.

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APA: Copy

EBRAHIMI VERKIYANI, M., SHIRAVI, A., & HOJATI, V.. (2018). THE EFFECTS OF TOPIRAMATE ANTIEPILEPTIC DRUG ON FETUS MALFORMATIONS IN NMRIMOUSE. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), 11(3 (42) ), 67-76. SID. https://sid.ir/paper/191734/en

Vancouver: Copy

EBRAHIMI VERKIYANI M., SHIRAVI A., HOJATI V.. THE EFFECTS OF TOPIRAMATE ANTIEPILEPTIC DRUG ON FETUS MALFORMATIONS IN NMRIMOUSE. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES)[Internet]. 2018;11(3 (42) ):67-76. Available from: https://sid.ir/paper/191734/en

IEEE: Copy

M. EBRAHIMI VERKIYANI, A. SHIRAVI, and V. HOJATI, “THE EFFECTS OF TOPIRAMATE ANTIEPILEPTIC DRUG ON FETUS MALFORMATIONS IN NMRIMOUSE,” JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), vol. 11, no. 3 (42) , pp. 67–76, 2018, [Online]. Available: https://sid.ir/paper/191734/en

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