Determining the Level of FGF12 Gene Transcript in the Tissue Samples of the Patients with Colorectal Cancer

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Khalafian Golshan; ENTEZARI MALIHEH

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Journal: JOURNAL OF DEVELOPMENTAL BIOLOGY Year:2019 | Volume:11 | Issue:3 Page(s): 13-22

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Title

Determining the Level of FGF12 Gene Transcript in the Tissue Samples of the Patients with Colorectal Cancer

Author(s)

Khalafian Golshan | ENTEZARI MALIHEH | Issue Writer Certificate

Keywords

Colorectal CancerQ1

FGF12Q1

BiomarkerQ1

RT-PCRQ1

Abstract

Colorectal Cancer is the fourth reason of mortality caused by cancer and it is one of the most common cancers of digestive system all over the world. Due to poor awareness with regard to the disease and also its high prevalence, early diagnosis of it is of paramount importance. A wide variety of studies has shown that the signaling pathway of fibroblast growth factor is among the effective pathways in growth and metastasis of tumor cells. Accordingly, this study is aimed at measuring the level of FGF12 gene transcript in tumor margin and tumor tissue of the patients with Colorectal Cancer. The total RNA was extracted from 30 tumor tissues and 30 healthy tissues in the patients with Colorectal Cancer and then cDNA was synthesized. The specific primers were designed for FGF12 gene as well as beta-actin and eventually, the mRNA level of the genes under study was measured through RT-PCR method and data analysis was done using REST and SPSS software. The results of this study showed that there has been an increase in FGF12 gene transcript in tumor tissue compared to the healthy tissue; but, the increase was not significant. In the analysis of the other factors, there was a significant difference in FGF12 gene transcript in the patients being at the stages 3 and 4 (High Stage) compared to the ones at the stages 1, 1 and 2 (Low Stage) (p=0. 043); while, there was no significant difference between the rate of the FGF12 gene transcript and the other clinical factors. Based on the increase in FGF12 gene transcript in the patients being at the stages 3 and 4 of Colorectal Cancer compared to the ones at the stages 0, 1, and 2, it can be stated that this gene plays a role in tumor creation of Colorectal Cancer.

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APA: Copy

Khalafian, Golshan, & ENTEZARI, MALIHEH. (2019). Determining the Level of FGF12 Gene Transcript in the Tissue Samples of the Patients with Colorectal Cancer. JOURNAL OF DEVELOPMENTAL BIOLOGY, 11(3 ), 13-22. SID. https://sid.ir/paper/193110/en

Vancouver: Copy

Khalafian Golshan, ENTEZARI MALIHEH. Determining the Level of FGF12 Gene Transcript in the Tissue Samples of the Patients with Colorectal Cancer. JOURNAL OF DEVELOPMENTAL BIOLOGY[Internet]. 2019;11(3 ):13-22. Available from: https://sid.ir/paper/193110/en

IEEE: Copy

Golshan Khalafian, and MALIHEH ENTEZARI, “Determining the Level of FGF12 Gene Transcript in the Tissue Samples of the Patients with Colorectal Cancer,” JOURNAL OF DEVELOPMENTAL BIOLOGY, vol. 11, no. 3 , pp. 13–22, 2019, [Online]. Available: https://sid.ir/paper/193110/en

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