Evaluation of cytotoxic effect of Ruta graveolens L. Hydro alcoholic extract in human cervical cancer cells (HeLa)

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MOUSAVI JAZAYERI SEYED MILAD; EBRAHIMI ELAHE; PARSANIA MASOUD

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Journal: JOURNAL OF DEVELOPMENTAL BIOLOGY Year:2019 | Volume:11 | Issue:1 Page(s): 27-34

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Title

Evaluation of cytotoxic effect of Ruta graveolens L. Hydro alcoholic extract in human cervical cancer cells (HeLa)

Author(s)

MOUSAVI JAZAYERI SEYED MILAD | EBRAHIMI ELAHE | PARSANIA MASOUD | Issue Writer Certificate

Keywords

Cytotoxic effectQ1

Ruta graveolens L.extractQ1

HeLa cellsQ1

Abstract

Introduction Cervical cancer is one of the most common cancers in women. In some cases, the lack of appropriate response to treatment with chemical drugs and the side effects of using synthetic drugs show necessary to achieve a natural drug that has minimal side effects. This study was evaluated effects of Hydroalcoholic extracts Ruta graveolens L. against of HeLa cell. Material and Methods HeLa cells were cultivated in Dulbecco’ s Modified Eagle’ s Medium (DMEM) supplemented with 10% fetal bovine serum. Preparation of extract were done by maceration technique. This study were assessed the effects of different concentrations (250, 500, 750, 1000 and 1500 μ g/ml) of Ruta graveolens L. on the proliferation of HeLa cells at 24, 48 and 72 hours after treatment of cells with extract and medium containing 1% serum by Trypan blue and MTT methods. Finding The cytotoxic concentration 50% (CC50) of the extract was determined on HeLa cell 1500 ug/ml. The results showed that concentrations of 1000 ug/ml of Ruta graveolens L. extract, after 72 hours showed a significant decrease in the proliferation of HeLa cells compared with control. Conclusion: The results of this study showed Ruta graveolens L. extract can inhibit the proliferation of HeLa cells. Keyword: Cytotoxic effect, Ruta graveolens L. extract, HeLa cells.

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APA: Copy

MOUSAVI JAZAYERI, SEYED MILAD, EBRAHIMI, ELAHE, & PARSANIA, MASOUD. (2019). Evaluation of cytotoxic effect of Ruta graveolens L. Hydro alcoholic extract in human cervical cancer cells (HeLa). JOURNAL OF DEVELOPMENTAL BIOLOGY, 11(1 ), 27-34. SID. https://sid.ir/paper/193113/en

Vancouver: Copy

MOUSAVI JAZAYERI SEYED MILAD, EBRAHIMI ELAHE, PARSANIA MASOUD. Evaluation of cytotoxic effect of Ruta graveolens L. Hydro alcoholic extract in human cervical cancer cells (HeLa). JOURNAL OF DEVELOPMENTAL BIOLOGY[Internet]. 2019;11(1 ):27-34. Available from: https://sid.ir/paper/193113/en

IEEE: Copy

SEYED MILAD MOUSAVI JAZAYERI, ELAHE EBRAHIMI, and MASOUD PARSANIA, “Evaluation of cytotoxic effect of Ruta graveolens L. Hydro alcoholic extract in human cervical cancer cells (HeLa),” JOURNAL OF DEVELOPMENTAL BIOLOGY, vol. 11, no. 1 , pp. 27–34, 2019, [Online]. Available: https://sid.ir/paper/193113/en

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