EVALUATION OF TOXIC EFFECTS OF TRIGONELLA FOENUM-GRAECUM LEAF AQUEOUS EXTRACT ON DEVELOPMENT OF LONG BONE TISSUE IN RATS’ FETUS

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AZARNIA MAHNAZ; MINAIE BAGHER; MOZAFFARI ZIBA; TAHAMTANI YASER

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Journal: JOURNAL OF DEVELOPMENTAL BIOLOGY Year:2009 | Volume:1 | Issue:1 Page(s): 49-58

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Title

EVALUATION OF TOXIC EFFECTS OF TRIGONELLA FOENUM-GRAECUM LEAF AQUEOUS EXTRACT ON DEVELOPMENT OF LONG BONE TISSUE IN RATS’ FETUS

Author(s)

AZARNIA MAHNAZ | MINAIE BAGHER | MOZAFFARI ZIBA | TAHAMTANI YASER | Issue Writer Certificate

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Abstract

In this study, investigated the adverse effects ofTrigonella foenum-graecum leaves aqueous extract (TGLE) on fetal development of hind limb long bone. TGLE was administered to pregnant rats by Intra peritoneal (i.p.) injection at the dose levels of 0.8, 1.6 and 3.2 (g/kg/day) on 10th day of gestation. Then all rats were sacrificed on 20th day of gestation and fetuses were removed of their uterus. The fetuses were assayed for histopathological signs of long bone. The treated group showed a correlation with histopathological changes of long bone tissue in their fetus. In conclusion, if only TGLE is used without consumption of any herbal plant concurrently, (1) TGLE has toxic potential on pregnant rats at the highest dose level (3.2 g/kg/day). This study shows that (2) the extract produces adverse effects on the development of hind limb long bone by disorder in the histology details of cell structure and growth into long bone during to endochondral ossification. Thus TGLE at the highest dose level the applicable dosage may cause severe adverse alterations in rat fetus. Proper clinical research should be carried out to confirm the same activity in human.

Cites

HISTOMORPHOMETRIC STUDY OF DIAZINON ON GROWTH PLATE OF RAT

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APA: Copy

AZARNIA, MAHNAZ, MINAIE, BAGHER, MOZAFFARI, ZIBA, & TAHAMTANI, YASER. (2009). EVALUATION OF TOXIC EFFECTS OF TRIGONELLA FOENUM-GRAECUM LEAF AQUEOUS EXTRACT ON DEVELOPMENT OF LONG BONE TISSUE IN RATS’ FETUS. JOURNAL OF DEVELOPMENTAL BIOLOGY, 1(1), 49-58. SID. https://sid.ir/paper/193151/en

Vancouver: Copy

AZARNIA MAHNAZ, MINAIE BAGHER, MOZAFFARI ZIBA, TAHAMTANI YASER. EVALUATION OF TOXIC EFFECTS OF TRIGONELLA FOENUM-GRAECUM LEAF AQUEOUS EXTRACT ON DEVELOPMENT OF LONG BONE TISSUE IN RATS’ FETUS. JOURNAL OF DEVELOPMENTAL BIOLOGY[Internet]. 2009;1(1):49-58. Available from: https://sid.ir/paper/193151/en

IEEE: Copy

MAHNAZ AZARNIA, BAGHER MINAIE, ZIBA MOZAFFARI, and YASER TAHAMTANI, “EVALUATION OF TOXIC EFFECTS OF TRIGONELLA FOENUM-GRAECUM LEAF AQUEOUS EXTRACT ON DEVELOPMENT OF LONG BONE TISSUE IN RATS’ FETUS,” JOURNAL OF DEVELOPMENTAL BIOLOGY, vol. 1, no. 1, pp. 49–58, 2009, [Online]. Available: https://sid.ir/paper/193151/en

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