ORAL MORPHINE CONSUMPTION IN PREGNANCY TIME AND LENS DEVELOPMENT IN THE WISTAR RAT EMBRYO

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TEKIEH ELAHEH; SAHRAEI HEDAYAT; RAMEZANI MINA; BAHADORAN HOSSEIN; KAZEMI MASOOMEH

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Journal: JOURNAL OF DEVELOPMENTAL BIOLOGY Year:2009 | Volume:1 | Issue:3 Page(s): 61-67

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Title

ORAL MORPHINE CONSUMPTION IN PREGNANCY TIME AND LENS DEVELOPMENT IN THE WISTAR RAT EMBRYO

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Keywords

MORPHINEQ2

CORTICOSTERONEQ3

VISUAL SYSTEMQ2

LENSQ2

RATQ2

Abstract

Lens is the most important component of the VISUAL SYSTEM in the regulation of insert light to retina.Induced Defect by MORPHINE in development of LENS result in dysfunction of VISUAL SYSTEM. In the present study, changes induced by MORPHINE in LENS area in the eyes of embryos whom their mothers received oral MORPHINE during pregnancy period were studied.Female Wistar RATs (250-300 g) were mated with male RATs and pregnancy was determined by sperm observation in vaginal smear. This day was considered as embryonic day zero (E0). The females then were divided randomly into the experimental and the control group. The control group received tap water where as the experimental group received MORPHINE (0.05 mg/ml) in their water. On the E13 blood samples were collected from the retro-orbital sinus of all animals for plasma CORTICOSTERONE detection. On the E17, the animals were killed by chloroform over dose and their embryos were taken out surgically. The embryos were fixed in formalin 10% for 30 days. At this time, the embryos’ head were removed for tissue processing, cutting and Hematoxylin- Eosin (H&E) staining. The samples were evaluated using light microscope and MOTIC soft ware.Our data indicated that plasma CORTICOSTERONE level was dramatically increased and the LENS area was thinner in the experimental group. Although the proliferation of LENS cells increased in the experiment group but that LENS had delay in removing the proliferated and elongation cells with abnormal density in the lateral part of the LENS in compare with control group.

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APA: Copy

TEKIEH, ELAHEH, SAHRAEI, HEDAYAT, RAMEZANI, MINA, BAHADORAN, HOSSEIN, & KAZEMI, MASOOMEH. (2009). ORAL MORPHINE CONSUMPTION IN PREGNANCY TIME AND LENS DEVELOPMENT IN THE WISTAR RAT EMBRYO. JOURNAL OF DEVELOPMENTAL BIOLOGY, 1(3), 61-67. SID. https://sid.ir/paper/193160/en

Vancouver: Copy

TEKIEH ELAHEH, SAHRAEI HEDAYAT, RAMEZANI MINA, BAHADORAN HOSSEIN, KAZEMI MASOOMEH. ORAL MORPHINE CONSUMPTION IN PREGNANCY TIME AND LENS DEVELOPMENT IN THE WISTAR RAT EMBRYO. JOURNAL OF DEVELOPMENTAL BIOLOGY[Internet]. 2009;1(3):61-67. Available from: https://sid.ir/paper/193160/en

IEEE: Copy

ELAHEH TEKIEH, HEDAYAT SAHRAEI, MINA RAMEZANI, HOSSEIN BAHADORAN, and MASOOMEH KAZEMI, “ORAL MORPHINE CONSUMPTION IN PREGNANCY TIME AND LENS DEVELOPMENT IN THE WISTAR RAT EMBRYO,” JOURNAL OF DEVELOPMENTAL BIOLOGY, vol. 1, no. 3, pp. 61–67, 2009, [Online]. Available: https://sid.ir/paper/193160/en

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