Evaluation of the effect of microgravity on the development of central vein in liver of rat embryos and therapeutic effect of folic acid

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Rahimi nia Pooneh; NASIRAEI MOGHADAM SHIVA; AZARNIA MAHNAZ; HAJEBRAHIMI ZAHRA

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Journal: JOURNAL OF DEVELOPMENTAL BIOLOGY Year:2018 | Volume:10 | Issue:4 (40) Page(s): 69-78

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Title

Evaluation of the effect of microgravity on the development of central vein in liver of rat embryos and therapeutic effect of folic acid

Author(s)

Rahimi nia Pooneh | NASIRAEI MOGHADAM SHIVA | AZARNIA MAHNAZ | HAJEBRAHIMI ZAHRA | Issue Writer Certificate

Keywords

central veinQ1

embryoQ1

liverQ1

MicrogravityQ2

RatQ2

Abstract

Microgravity has many effects on the physiological systems. Studying these changes is useful to help astronauts, improve human life and to answer biology questions. The aim of present study was to investigate the impact of Microgravity on the development of central vein in Rat embryos and therapeatic effect of folic acid. Fertilization animals were randomly divided into five groups: control group, the first experimental group who were exposed to Microgravity (days 10-15 of pregnancy), the second experimental group who received an edible daily dose of Folic acid (days 10-15 of pregnancy), the third experimental group who were exposed to Microgravity (days 1-19. 5 of pregnancy), the fourth experimental group who received Folic acid and exposed to Microgravity (days 10-15 of pregnancy). Hindlimb unloading model was used to establish ground-based-model of Microgravity. On the 20th day of pregnancy, the embryo was removed, fixed, stained using H&E, and studied under the microscope. Data analyzed using SPSS and One-way ANOVA and Tukey test. The results indicated that exposure to Microgravity can produce abnormal central vein. Although folic acid consumption alone does not show a meaningful impact, its consumption combined with Microgravity can improve central vein morphology that suggests no need for folic acid in normal condition.

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APA: Copy

Rahimi nia, Pooneh, NASIRAEI MOGHADAM, SHIVA, AZARNIA, MAHNAZ, & HAJEBRAHIMI, ZAHRA. (2018). Evaluation of the effect of microgravity on the development of central vein in liver of rat embryos and therapeutic effect of folic acid. JOURNAL OF DEVELOPMENTAL BIOLOGY, 10(4 (40) ), 69-78. SID. https://sid.ir/paper/193178/en

Vancouver: Copy

Rahimi nia Pooneh, NASIRAEI MOGHADAM SHIVA, AZARNIA MAHNAZ, HAJEBRAHIMI ZAHRA. Evaluation of the effect of microgravity on the development of central vein in liver of rat embryos and therapeutic effect of folic acid. JOURNAL OF DEVELOPMENTAL BIOLOGY[Internet]. 2018;10(4 (40) ):69-78. Available from: https://sid.ir/paper/193178/en

IEEE: Copy

Pooneh Rahimi nia, SHIVA NASIRAEI MOGHADAM, MAHNAZ AZARNIA, and ZAHRA HAJEBRAHIMI, “Evaluation of the effect of microgravity on the development of central vein in liver of rat embryos and therapeutic effect of folic acid,” JOURNAL OF DEVELOPMENTAL BIOLOGY, vol. 10, no. 4 (40) , pp. 69–78, 2018, [Online]. Available: https://sid.ir/paper/193178/en

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