Heart Reaction to Nandrolone Decanoate plus Two Different Intensities of Endurance Exercise: Electrocardiography and Stereological Approach

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JOUKAR SIYAVASH; Yoosefnia Mahdieh; Naderi Boldaji Vida; NASRI HAMIDREZA; RAFIE FOROUZAN

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Journal: Addiction and Health Year:2018 | Volume:10 | Issue:3 Page(s): 180-189

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Title

Heart Reaction to Nandrolone Decanoate plus Two Different Intensities of Endurance Exercise: Electrocardiography and Stereological Approach

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Nandrolone decanoateQ1

ExerciseQ1

ElectrocardiographyQ1

HistologyQ1

Abstract

Background: Regarding the negative effects of androgenic anabolic steroids (AASs) abuse, the long-term effect of Nandrolone decanoate with/without two intensities of endurance Exercise training was investigated on heart tissue and electrocardiogram (ECG) in rats. Methods: The experiment was conducted on 63 male Wistar rats, which were 4 months old. The rats were divide into groups of control (CTL), arachis oilasnandrolone solvent (Ar), nandrolone (Nan) (received a dose of 5 mg/kg twice/week for 8 weeks), mild swimming Exercise training (mEx), severe Exercise (sEx), sEx + Nan, mEx + Nan, mEx + Ar, and sEx + Ar. During the 8 weeks of swimming Exercise, the animals carried dumbbells equivalent to 2% of their body weight, which was gradually increased and reached 5% and 8% in the 6th week for mild and severe Exercises, respectively. Finally, ECGs recording and samplings were done. Findings: Both types of Exercise, without nandrolone, significantly reduced the heart rate and increased the RR interval of ECG. Nandrolone alone and with mild (P < 0. 050) and intense Exercise (P < 0. 010 vs. CTL) increased the left ventricular hypertrophy (LVH) index. Left ventricular volume was significantly higher in the Nan group (P < 0. 050) compared to the CTL group and all Exercise groups (P < 0. 010) compared to the Nan, CTL, and Ar groups. Myocytes volume increased in the presence of both of mild and high-intensity Exercise plus nandrolone (P < 0. 050 vs. CTL and Ar groups). Hydroxyproline value of the heart was significantly higher in the nandrolone group compared to all other groups (P < 0. 001). Exercise prevented the effect of nandrolone on hydroxyproline. Conclusion: Both levels of swimming Exercise prevent the effect of nandrolone on the production of hydroxyproline and fibrotic cardiac remodeling.

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APA: Copy

Yoosefnia, Mahdieh, Naderi Boldaji, Vida, NASRI, HAMIDREZA, & RAFIE, FOROUZAN. (2018). Heart Reaction to Nandrolone Decanoate plus Two Different Intensities of Endurance Exercise: Electrocardiography and Stereological Approach. ADDICTION AND HEALTH, 10(3 ), 180-189. SID. https://sid.ir/paper/194321/en

Vancouver: Copy

Yoosefnia Mahdieh, Naderi Boldaji Vida, NASRI HAMIDREZA, RAFIE FOROUZAN. Heart Reaction to Nandrolone Decanoate plus Two Different Intensities of Endurance Exercise: Electrocardiography and Stereological Approach. ADDICTION AND HEALTH[Internet]. 2018;10(3 ):180-189. Available from: https://sid.ir/paper/194321/en

IEEE: Copy

Mahdieh Yoosefnia, Vida Naderi Boldaji, HAMIDREZA NASRI, and FOROUZAN RAFIE, “Heart Reaction to Nandrolone Decanoate plus Two Different Intensities of Endurance Exercise: Electrocardiography and Stereological Approach,” ADDICTION AND HEALTH, vol. 10, no. 3 , pp. 180–189, 2018, [Online]. Available: https://sid.ir/paper/194321/en

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