DOES EXERCISE DEPRIVATION INCREASE THE TENDENCY TOWARDS MORPHINE DEPENDENCE IN RATS?

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NAKHAEE MOHAMMAD REZA; SHEIBANI VAHID; GHAHRAMAN TABRIZI KOUROSH; MAREFATI HAMID; BAHREINIFAR SAREH; NAKHAEE NOUZAR

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Journal: Addiction and Health Year:2010 | Volume:2 | Issue:3-4 Page(s): 74-80

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Title

DOES EXERCISE DEPRIVATION INCREASE THE TENDENCY TOWARDS MORPHINE DEPENDENCE IN RATS?

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Keywords

EXERCISE DEPENDENCEQ3

SUBSTANCE DEPENDENCEQ3

ORAL MORPHINE SELFADMINISTRATIONQ3

RATQ3

Abstract

Background: Exercise deprivation has been concluded to have some negative effects on psychological well-being. This study was conducted to find out whether exercise deprivation may lead to morphine dependence in RATs.Methods: Forty male Wistar RATs weighing 162±9 g were housed in clear plastic cages in groups of two under standard laboratory conditions. The study had two phases. In phase I, the animals were randomly divided into exercised (E) and unexercised (UE) groups (n=20 each) and treadmill running was performed based on a standard protocol for three weeks. At the end of the training period, plasma b -endorphin levels were determined in four RATs from each group. In phase II, the animals were provided with two bottles, one containing tap water and the other 25 mg/l morphine sulfate in tap water for a total of 12 weeks. At the end of this phase naloxone was injected intraperitoneally to precipitate morphine withdrawal.Findings: There was no significant difference between UE and E groups in morphine consumption (mg/kg/wk) [group: F (1, 14) =0.2, P=0.690; time: F(11, 154) =18.72, P<0.001; interaction: F (11, 154) =1.27, P=0.245]. No statistically significant difference between the two groups of animals was seen regarding withdrawal signs.Conclusion: The study showed that discontinuation of exercise does not increase the tendency of morphine dependence in RATs.

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APA: Copy

NAKHAEE, MOHAMMAD REZA, SHEIBANI, VAHID, GHAHRAMAN TABRIZI, KOUROSH, MAREFATI, HAMID, BAHREINIFAR, SAREH, & NAKHAEE, NOUZAR. (2010). DOES EXERCISE DEPRIVATION INCREASE THE TENDENCY TOWARDS MORPHINE DEPENDENCE IN RATS?. ADDICTION AND HEALTH, 2(3-4), 74-80. SID. https://sid.ir/paper/194343/en

Vancouver: Copy

NAKHAEE MOHAMMAD REZA, SHEIBANI VAHID, GHAHRAMAN TABRIZI KOUROSH, MAREFATI HAMID, BAHREINIFAR SAREH, NAKHAEE NOUZAR. DOES EXERCISE DEPRIVATION INCREASE THE TENDENCY TOWARDS MORPHINE DEPENDENCE IN RATS?. ADDICTION AND HEALTH[Internet]. 2010;2(3-4):74-80. Available from: https://sid.ir/paper/194343/en

IEEE: Copy

MOHAMMAD REZA NAKHAEE, VAHID SHEIBANI, KOUROSH GHAHRAMAN TABRIZI, HAMID MAREFATI, SAREH BAHREINIFAR, and NOUZAR NAKHAEE, “DOES EXERCISE DEPRIVATION INCREASE THE TENDENCY TOWARDS MORPHINE DEPENDENCE IN RATS?,” ADDICTION AND HEALTH, vol. 2, no. 3-4, pp. 74–80, 2010, [Online]. Available: https://sid.ir/paper/194343/en

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