ANTI-ENDOMYSIAL AND ANTI-TISSUE TRANSGLUTAMINASE SEROLOGICAL TEST COMPARED WITH SMALL BOWEL BIOPSY IN THE DIAGNOSIS OF CELIAC DISEASE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHADMAN M.; ABEDIAN KENARI S.; ALIZADEH A.; KAVEH M.; HOSSEINI V.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: MEDICAL LABORATORY JOURNAL Year:2013 | Volume:7 | Issue:3 Page(s): 46-53

Download Full-Text

Persian Verion

View:

1,047

Download:

Cites:

Information Journal Paper

Title

ANTI-ENDOMYSIAL AND ANTI-TISSUE TRANSGLUTAMINASE SEROLOGICAL TEST COMPARED WITH SMALL BOWEL BIOPSY IN THE DIAGNOSIS OF CELIAC DISEASE

Author(s)

Keywords

CELIACQ3

ANTI-TISSUE TRANSGLUTAMINASE (TTG)Q2

ANTI-ENDOMYSIAL (EMA)Q2

Abstract

Background and Objective: CELIAC is an autoimmune disease that is characterized by an immune-system-related damage in the intestinal tissue after consumption of gluten. There is not any general agreement for gold standard. The Purpose of this study was the evaluation of specificity and sensitivity of anti-endomysial (EMA) and anti-tissue transglutaminase (TTG) serological test compared to small-bowel biopsy.Material and Methods: In the cross sectional study, we took blood specimen from 1825 patients with gastrointestinal disease. All the samples were tested by TTG and EMA kits using ELISA. The patients were studied in two groups. First, the individuals whom their serologic test was positive but their tissue condition was normal and second, those with positive serologic test with pathologic tissue results that show they have CELIAC disorder.Results: The mean of EMA and TTG shows that the level of antibodies in group 2 is significantly higher than that of the first group (P£0.001). There is positive correlation between modified marsh criteria of small-bowel biopsy and the two tests. The Sensitivity of EMA and TTG tests for CELIAC diagnosis is 92%. The specificity of EMA, TTG tests are 100% and 98.5%, respectively.Conclusion: EMA-IgA serology with cut-off point of more than 66 together with TTG-IgA serology with cut-off point of above 30 can be helpful to distinguish a wide range of patients who need small-bowel biopsy.

Cites

No record.

References

No record.

Cite

APA: Copy

SHADMAN, M., ABEDIAN KENARI, S., ALIZADEH, A., KAVEH, M., & HOSSEINI, V.. (2013). ANTI-ENDOMYSIAL AND ANTI-TISSUE TRANSGLUTAMINASE SEROLOGICAL TEST COMPARED WITH SMALL BOWEL BIOPSY IN THE DIAGNOSIS OF CELIAC DISEASE. MEDICAL LABORATORY JOURNAL, 7(3), 46-53. SID. https://sid.ir/paper/194710/en

Vancouver: Copy

SHADMAN M., ABEDIAN KENARI S., ALIZADEH A., KAVEH M., HOSSEINI V.. ANTI-ENDOMYSIAL AND ANTI-TISSUE TRANSGLUTAMINASE SEROLOGICAL TEST COMPARED WITH SMALL BOWEL BIOPSY IN THE DIAGNOSIS OF CELIAC DISEASE. MEDICAL LABORATORY JOURNAL[Internet]. 2013;7(3):46-53. Available from: https://sid.ir/paper/194710/en

IEEE: Copy

M. SHADMAN, S. ABEDIAN KENARI, A. ALIZADEH, M. KAVEH, and V. HOSSEINI, “ANTI-ENDOMYSIAL AND ANTI-TISSUE TRANSGLUTAMINASE SEROLOGICAL TEST COMPARED WITH SMALL BOWEL BIOPSY IN THE DIAGNOSIS OF CELIAC DISEASE,” MEDICAL LABORATORY JOURNAL, vol. 7, no. 3, pp. 46–53, 2013, [Online]. Available: https://sid.ir/paper/194710/en

Related Journal Papers