THE IDENTIFICATION OF MALIGNANT CELLS IN SEROUS FLUIDS USING A PANEL OF MONOCLONAL CYTOKERATIN ANTIBODIES, EPITHELIAL MEMBRANE ANTIGEN (EMA), CARCINO EMBRYONIC ANTIGEN (CEA)

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KAZEMINEJAD V.; AZARHOOSH R.

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Journal: MEDICAL LABORATORY JOURNAL Year:2014 | Volume:7 | Issue:4 Page(s): 41-46

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Title

THE IDENTIFICATION OF MALIGNANT CELLS IN SEROUS FLUIDS USING A PANEL OF MONOCLONAL CYTOKERATIN ANTIBODIES, EPITHELIAL MEMBRANE ANTIGEN (EMA), CARCINO EMBRYONIC ANTIGEN (CEA)

Author(s)

KAZEMINEJAD V. | AZARHOOSH R. | Issue Writer Certificate

Keywords

MONOCLONAL ANTIBODYQ2

CYTOKERATINQ2

EPITHELIAL MEMBERANE ANTIGENQ2

CARCINOEMBERYONIC ANTIGENQ2

Abstract

Background and Objective: Identification of malignant cells and the type of malignancy in Effusionsis very important. The main aim of this study was to differentiate between reactive mesothelial cells and malignant cells; and to determine the type of the tumor cells in effusions with the aid of tumor markers Creatine Kinase (CK), EMA and CEA.Material and Methods: Forty serous fluid cytology samples delivered to pathology laboratory of Panje- Azar Hospital (15 were malignant and 25 were suspected for malignancy) were stained by immunocytochemistry technique with the aid of aforementioned tumor markers, CK, EMA and CEA.Results: Of 15 malignancy cases, 13 were positive for three markers and the rest were negative just for CEA. In 25 of suspected to malignancy for EMA: 15 were strongly and 6 weakly positive and 4 were negative; for CK: 10 were strongly and 5 weakly positive and 5 cases were negative; and for CEA: 5 were strongly and 5 weakly positive and 15 were negative.Conclusion: Totally, % 87.5 of malignant fluid were positive for CK marker and %90 for EMA marker. EMA and CK were found to be the most reliable epithelial markers and very useful in differentiating carcinoma cells from reactive mesithelial cells. In Ten (40%) of the samples suspected to adenocarcinoma, CEA was positive and this indicate that CEA can be an important reference for identifying malignant effusions.

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APA: Copy

KAZEMINEJAD, V., & AZARHOOSH, R.. (2014). THE IDENTIFICATION OF MALIGNANT CELLS IN SEROUS FLUIDS USING A PANEL OF MONOCLONAL CYTOKERATIN ANTIBODIES, EPITHELIAL MEMBRANE ANTIGEN (EMA), CARCINO EMBRYONIC ANTIGEN (CEA). MEDICAL LABORATORY JOURNAL, 7(4), 41-46. SID. https://sid.ir/paper/194762/en

Vancouver: Copy

KAZEMINEJAD V., AZARHOOSH R.. THE IDENTIFICATION OF MALIGNANT CELLS IN SEROUS FLUIDS USING A PANEL OF MONOCLONAL CYTOKERATIN ANTIBODIES, EPITHELIAL MEMBRANE ANTIGEN (EMA), CARCINO EMBRYONIC ANTIGEN (CEA). MEDICAL LABORATORY JOURNAL[Internet]. 2014;7(4):41-46. Available from: https://sid.ir/paper/194762/en

IEEE: Copy

V. KAZEMINEJAD, and R. AZARHOOSH, “THE IDENTIFICATION OF MALIGNANT CELLS IN SEROUS FLUIDS USING A PANEL OF MONOCLONAL CYTOKERATIN ANTIBODIES, EPITHELIAL MEMBRANE ANTIGEN (EMA), CARCINO EMBRYONIC ANTIGEN (CEA),” MEDICAL LABORATORY JOURNAL, vol. 7, no. 4, pp. 41–46, 2014, [Online]. Available: https://sid.ir/paper/194762/en

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