ANTIBACTERIAL EFFICACY OF BIOGENIC GOLD NANOPARTICLE-GENTAMICIN CONJUGATE ON STAPHYLOCOCCUS AUREUS

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AHANGARI A.; SALOUTI M.; HEIDARI Z.; MOHAMMADI B.; ZARE S.; GHAMARI D.; TARAN J.; FARAHMANDKIA Z.; DOLATYARI L.

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Journal: JOURNAL OF ZABOL UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES (JOURNAL OF ROSTAMINEH) Year:2012 | Volume:4 | Issue:3 Page(s): 9-20

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Title

ANTIBACTERIAL EFFICACY OF BIOGENIC GOLD NANOPARTICLE-GENTAMICIN CONJUGATE ON STAPHYLOCOCCUS AUREUS

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Keywords

STAPHYLOCOCCUS AUREUSQ2

ANTIBACTERIAL ACTIVITYQ2

GENTAMICIN- BIOGENIC GOLD NANOPARTICLES CONJUGATEQ2

Abstract

Introduction: Bacterial infections continue to be one of the major causes of morbidity and mortality in most countries especially in developing countries. The use of gold nanoparticles conjugated with antibiotics is a promising approach for enhancement of therapeutic effect of the antibiotics on infecteous wounds and foci. The aim of this study was to bind gentamicin to biogenic gold nanoparticles to evaluate antimicrobial effect of the new nanodrug against STAPHYLOCOCCUS AUREUS.Methods: In the present study, gold nanoparticles were biologically synthesized using the fungus Aspergillus flavus. The production of gold nanoparticles was characterized by observing the color changing of the reaction mixrure, UV-vis spectroscopy and scanning electron microscopy. The concentration of gold nanoparticles was determined by atomic absorption spectroscopy. The biogenic gold nanoparticles were conjugated with gentamicin (1mg/ml concentration).Minimum inhibitory concentration and minimum bactericidal concentration of the conjugate and gentamicin was investigated by liquid broth dilution method.Results: The results showed that gold nanoparticles have been produced extracellular in spherical shape and in the size range of 200-250 nm. The concentration of biogenic gold nanoparticles was determined 2.63 mg/l. It was also found that, based on the liquid broth dilution test. MIC of the conjugate and free gentamicin were 0.015 and 0.0312 mg/ml, respectively and MBC of the conjugate and free gentamicin were 0.312 and 0.0625 mg/ml, respectively that showed the enhancement of antibacterial effect of the conjugate in comparison with free gentamicin.Conclusion: This study elucidated that conjugation of biogenic gold nanoparticles with gentamicin enhances the antibacterial effect of gentamicin against STAPHYLOCOCCUS AUREUS.

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APA: Copy

AHANGARI, A., SALOUTI, M., HEIDARI, Z., MOHAMMADI, B., ZARE, S., GHAMARI, D., TARAN, J., FARAHMANDKIA, Z., & DOLATYARI, L.. (2012). ANTIBACTERIAL EFFICACY OF BIOGENIC GOLD NANOPARTICLE-GENTAMICIN CONJUGATE ON STAPHYLOCOCCUS AUREUS. JOURNAL OF ZABOL UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES (JOURNAL OF ROSTAMINEH), 4(3), 9-20. SID. https://sid.ir/paper/203574/en

Vancouver: Copy

AHANGARI A., SALOUTI M., HEIDARI Z., MOHAMMADI B., ZARE S., GHAMARI D., TARAN J., FARAHMANDKIA Z., DOLATYARI L.. ANTIBACTERIAL EFFICACY OF BIOGENIC GOLD NANOPARTICLE-GENTAMICIN CONJUGATE ON STAPHYLOCOCCUS AUREUS. JOURNAL OF ZABOL UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES (JOURNAL OF ROSTAMINEH)[Internet]. 2012;4(3):9-20. Available from: https://sid.ir/paper/203574/en

IEEE: Copy

A. AHANGARI, M. SALOUTI, Z. HEIDARI, B. MOHAMMADI, S. ZARE, D. GHAMARI, J. TARAN, Z. FARAHMANDKIA, and L. DOLATYARI, “ANTIBACTERIAL EFFICACY OF BIOGENIC GOLD NANOPARTICLE-GENTAMICIN CONJUGATE ON STAPHYLOCOCCUS AUREUS,” JOURNAL OF ZABOL UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES (JOURNAL OF ROSTAMINEH), vol. 4, no. 3, pp. 9–20, 2012, [Online]. Available: https://sid.ir/paper/203574/en

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