THE HEALING EFFECT OF HYDROALCOHOLIC EXTRACT OF HYPERICUM PERFORATUM ON ACETIC ACID-INDUCED ULCERATIVE COLITIS IN MALE RATS

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TANIDEH N.; NEMATOLLAHI S.L.; HOSSEINI S.V.; HOSSEINZADEH M.; MEHRABANI D.; SAFARPOUR A.; SEPEHRIMANESH M.; KOOHI HOSSEINABADI O.; NAJIBI A.

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Journal: JOURNAL OF ADVANCED BIOMEDICAL SCIENCES Year:2017 | Volume:6 | Issue:4 Page(s): 530-537

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Title

THE HEALING EFFECT OF HYDROALCOHOLIC EXTRACT OF HYPERICUM PERFORATUM ON ACETIC ACID-INDUCED ULCERATIVE COLITIS IN MALE RATS

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Keywords

HYPERICUM PERFORATUMQ2

INFLAMMATORY BOWEL DISEASEQ2

ULCERATIVE COLITISQ1

MALONDIALDEHYDEQ2

Abstract

Background & Objective: Anti-inflammatory effect of Hypericum have long been considered. ULCERATIVE COLITIS (UC) is a form of INFLAMMATORY BOWEL DISEASE (IBD). In this study, the effects of HYPERICUM PERFORATUM on histopathological changes and tissue MALONDIALDEHYDE (MDA) level of colonic tissue in rats with induced UC were evaluated.Materials & Methods: 70 rats were divided into seven equal groups. Colitis was induced by acetic acid. Groups I and II received 1 mL of 600 and 300 mg/kg H. perforatum extract orally per day respectively; groups III and IV received 1 mL of 20% and 10% intra-colonic gel form of H. perforatum extract daily espectively; group V, as positive control, received 1 mL of intra-colonic Asacol; group VI received 1 mL of normal saline as negative control; group VII received just intra-colonic gel base. All the animals were evaluated for histological changes and tissue MDA level of colon seven days after the treatment. Results: H. perforatum extract in the two forms of trans-rectal and oral administration could result in a more healing effect on acetic acid-induced damaged colonic tissue with a reduction in the MDA activity .In trans-rectal administration, the 20% gel had a better healing response than the 10% gel. In oral administration, the 600 mg/kg dosage had a better healing response than the 300 mg/kg.Conclusions: Therefor, H. perforatum can be considered as a treatment of choice for UC especially in trans-rectal gel form.

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APA: Copy

TANIDEH, N., NEMATOLLAHI, S.L., HOSSEINI, S.V., HOSSEINZADEH, M., MEHRABANI, D., SAFARPOUR, A., SEPEHRIMANESH, M., KOOHI HOSSEINABADI, O., & NAJIBI, A.. (2017). THE HEALING EFFECT OF HYDROALCOHOLIC EXTRACT OF HYPERICUM PERFORATUM ON ACETIC ACID-INDUCED ULCERATIVE COLITIS IN MALE RATS. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 6(4), 530-537. SID. https://sid.ir/paper/203839/en

Vancouver: Copy

TANIDEH N., NEMATOLLAHI S.L., HOSSEINI S.V., HOSSEINZADEH M., MEHRABANI D., SAFARPOUR A., SEPEHRIMANESH M., KOOHI HOSSEINABADI O., NAJIBI A.. THE HEALING EFFECT OF HYDROALCOHOLIC EXTRACT OF HYPERICUM PERFORATUM ON ACETIC ACID-INDUCED ULCERATIVE COLITIS IN MALE RATS. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2017;6(4):530-537. Available from: https://sid.ir/paper/203839/en

IEEE: Copy

N. TANIDEH, S.L. NEMATOLLAHI, S.V. HOSSEINI, M. HOSSEINZADEH, D. MEHRABANI, A. SAFARPOUR, M. SEPEHRIMANESH, O. KOOHI HOSSEINABADI, and A. NAJIBI, “THE HEALING EFFECT OF HYDROALCOHOLIC EXTRACT OF HYPERICUM PERFORATUM ON ACETIC ACID-INDUCED ULCERATIVE COLITIS IN MALE RATS,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 6, no. 4, pp. 530–537, 2017, [Online]. Available: https://sid.ir/paper/203839/en

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