ASSOCIATION OF RS16953002 FTO GENE POLYMORPHISM WITH TYPE 2 DIABETES AND OBESITY

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BAKHSHI GANJE M.; SHEIKHHA M.H.; FARASHAHI E.; MOHAMMADZADE M.

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Journal: JOURNAL OF ADVANCED BIOMEDICAL SCIENCES Year:2016 | Volume:6 | Issue:1 Page(s): 27-34

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Title

ASSOCIATION OF RS16953002 FTO GENE POLYMORPHISM WITH TYPE 2 DIABETES AND OBESITY

Author(s)

BAKHSHI GANJE M. | SHEIKHHA M.H. | FARASHAHI E. | MOHAMMADZADE M. | Issue Writer Certificate

Keywords

FTO GENEQ1

TYPE 2 DIABETESQ2

OBESITYQ2

POLYMORPHISMQ2

Abstract

Background & Objective: Genome-wide association studies (GWAS) has identified that FTO GENE POLYMORPHISMs was associated with the risk of TYPE 2 DIABETES and OBESITY. However, the findings in subsequent studies were inconsistent in various populations. This study aimed to investigate the association of FTO rs16953002 with TYPE 2 DIABETES and OBESITY in Yazd, Iran.Methods & Materials: Unrelated study subject controls (n=200) and TYPE 2 DIABETES cases (T2DM) (n=200), were randomly selected from Yazd, Iran. Genotyping was done by the polymerase chain reaction-restriction fragment length POLYMORPHISM method. Age and gender, smoking, weight and body mass index (BMI) were analyzed using the analysis of c2 test.Results: The rs16953002 A/G POLYMORPHISM of the FTO GENE showed significant association with T2DM and OBESITY. The AG, GG genotypes were significantly higher in T2DM and obese subjects compared to the group subjects.Conclusions: The result of the present study indicate that the genetic variant in FTO may contribute to T2DM and OBESITY risk in Yazd population.

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APA: Copy

BAKHSHI GANJE, M., SHEIKHHA, M.H., FARASHAHI, E., & MOHAMMADZADE, M.. (2016). ASSOCIATION OF RS16953002 FTO GENE POLYMORPHISM WITH TYPE 2 DIABETES AND OBESITY. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 6(1), 27-34. SID. https://sid.ir/paper/203935/en

Vancouver: Copy

BAKHSHI GANJE M., SHEIKHHA M.H., FARASHAHI E., MOHAMMADZADE M.. ASSOCIATION OF RS16953002 FTO GENE POLYMORPHISM WITH TYPE 2 DIABETES AND OBESITY. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2016;6(1):27-34. Available from: https://sid.ir/paper/203935/en

IEEE: Copy

M. BAKHSHI GANJE, M.H. SHEIKHHA, E. FARASHAHI, and M. MOHAMMADZADE, “ASSOCIATION OF RS16953002 FTO GENE POLYMORPHISM WITH TYPE 2 DIABETES AND OBESITY,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 6, no. 1, pp. 27–34, 2016, [Online]. Available: https://sid.ir/paper/203935/en

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