Up-regulation of JAK2 Gene in Patients with Acute Myeloid Leukemia

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MORADI Z.; ONSORY KHADIJEH

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Journal: JOURNAL OF ADVANCED BIOMEDICAL SCIENCES Year:2019 | Volume:8 | Issue:4 Page(s): 1157-1166

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Title

Up-regulation of JAK2 Gene in Patients with Acute Myeloid Leukemia

Author(s)

MORADI Z. | ONSORY KHADIJEH | Issue Writer Certificate

Keywords

Acute Myeloid LeukemiaQ2

JAK2 geneQ1

Real-time PCRQ1

Abstract

Background & Objective: Acute Myeloid Leukemia (AML) is the third most prevalent type of cancer in Iran and fifth in the world, which includes 8% of the whole type of cancers. The Janus kinase and transcription activator (JAK-STAT) pathway plays pivotal roles in the regulation of cell proliferation, differentiation, migration and apoptosis, which is closely related with the development of some hematological diseases. The JAK-STAT is an important signaling pathway which abnormal inactivation of that is involved in leukemia development. One of the important genes in this signaling pathway is JAK2 and the purpose of this study was to evaluate the JAK2 gene expression in AML patients and compare it with control group. Materials & methods: In this case-control study, blood sample from 30 AML patients admitted to Mirzakochak Khan Jangli Hospital, in Tehran in 1395 and 20 healthy individuals as control were collected. RNA was extracted and after cDNA synthesis, the expression of JAK2 gene was evaluated using Real time PCR (Δ Δ CT computational). Statistical analysis was performed through software Graphpad prism 6, using t-test and P<0. 05 was considered significant. Results: The results showed there was a statistically significant association between increasing in JAK2 gene expression in patients compared to the control group (P=0. 0001). While no correlation was observed between the age (P=0. 753) and sex (P=0. 494) of patients with JAK2 gene up-regulation in the studied population. Conclusion: Investigating the rate of JAK2 gene expression, can play a significant role in the precaution of patients afflicted with AML.

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APA: Copy

MORADI, Z., & ONSORY, KHADIJEH. (2019). Up-regulation of JAK2 Gene in Patients with Acute Myeloid Leukemia. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 8(4 ), 1157-1166. SID. https://sid.ir/paper/203968/en

Vancouver: Copy

MORADI Z., ONSORY KHADIJEH. Up-regulation of JAK2 Gene in Patients with Acute Myeloid Leukemia. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2019;8(4 ):1157-1166. Available from: https://sid.ir/paper/203968/en

IEEE: Copy

Z. MORADI, and KHADIJEH ONSORY, “Up-regulation of JAK2 Gene in Patients with Acute Myeloid Leukemia,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 8, no. 4 , pp. 1157–1166, 2019, [Online]. Available: https://sid.ir/paper/203968/en

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