The Effects of Fasciola Hepatica on Acetic acid Induced Ulcerative Colitis in Rat Model

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ESMAEILNEJAD Bizhan; ABTAHI FROUSHANI S.M.; TEHRANI A.A.; ESMAEILI GOUVARCHIN GHALEH H.; Moshrefzadeh F.

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Journal: JOURNAL OF ADVANCED BIOMEDICAL SCIENCES Year:2019 | Volume:8 | Issue:4 Page(s): 1136-1145

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Title

The Effects of Fasciola Hepatica on Acetic acid Induced Ulcerative Colitis in Rat Model

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Keywords

Ulcerative colitisQ2

Acetic acidQ2

RatQ2

Fasciola hepaticaQ2

inflammationQ2

Abstract

Background & Objective: Rative colitis/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">UlceRative colitis is one of the common causes of gastrointestinal tract diseases in developing countries. This disease causes disability, especially in young adults, and imposes many social and economic burdens on the community. The aim of this study was to investigate the effects of Fasciola hepatica extract on Acetic acid induced Rative colitis/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">UlceRative colitis in Rat model. Materials & Methods: Thirty adult male Wistar Rats were divided into 3 equal groups. Colitis was induced by the administRation of 4% Acetic acid. Control group just was administRated phosphatebufferedsaline (S. C. ) and the other groups were received Prednisolone (0. 5 mg/kg) and Fasciola hepatica extract (100 mg/kg) for 10 consecutive days. Since then, the animals were euthanized and intestinal tissue and blood samples were taken. Macroscopic and microscopic features, inflammatory mediators as well as cytokines, TNF-α and IL-6 were assessed. Results: The amount of the myeloperoxidase production was the same between the two treatment groups. As compared to the control, both of the treatment groups produced lower amount of TNF-α and IL-6, however this reduction was more pronounced in Prednisolone-induced animals than those of extract-induced. There were no significant differences between Prednisolone and Fasciola extract regarding gross damages and histopathological features. Conclusion: since the prepaRation of Fasciola extract is easy and simple, it may be used as amelioRative agent for Rative colitis/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">UlceRative colitis.

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APA: Copy

ESMAEILNEJAD, Bizhan, ABTAHI FROUSHANI, S.M., TEHRANI, A.A., ESMAEILI GOUVARCHIN GHALEH, H., & Moshrefzadeh, F.. (2019). The Effects of Fasciola Hepatica on Acetic acid Induced Ulcerative Colitis in Rat Model. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 8(4 ), 1136-1145. SID. https://sid.ir/paper/203971/en

Vancouver: Copy

ESMAEILNEJAD Bizhan, ABTAHI FROUSHANI S.M., TEHRANI A.A., ESMAEILI GOUVARCHIN GHALEH H., Moshrefzadeh F.. The Effects of Fasciola Hepatica on Acetic acid Induced Ulcerative Colitis in Rat Model. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2019;8(4 ):1136-1145. Available from: https://sid.ir/paper/203971/en

IEEE: Copy

Bizhan ESMAEILNEJAD, S.M. ABTAHI FROUSHANI, A.A. TEHRANI, H. ESMAEILI GOUVARCHIN GHALEH, and F. Moshrefzadeh, “The Effects of Fasciola Hepatica on Acetic acid Induced Ulcerative Colitis in Rat Model,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 8, no. 4 , pp. 1136–1145, 2019, [Online]. Available: https://sid.ir/paper/203971/en

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