New Techniques and Methods in the Study of the Invasion, Cell Migration and MMPs Activity in Vitro and in Animal Models

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GOLESTANI A.; Abdollahipour Haghighi R.; TAKHSHID M.A.; ARABSOLGHAR R.

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Paper Information

Journal: Journal of Advanced Biomedical Sciences Year:2019 | Volume:8 | Issue:4 Page(s): 1000-1011

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Title

New Techniques and Methods in the Study of the Invasion, Cell Migration and MMPs Activity in Vitro and in Animal Models

Author(s)

GOLESTANI A. | Abdollahipour Haghighi R. | TAKHSHID M.A. | ARABSOLGHAR R. | Issue Writer Certificate

Keywords

malignant tumorQ2

matrix metalloproteinase enzymeQ1

cell migration assaysQ2

Abstract

Background & Objective: Cancer metastasis is the primary cause of cancer morbidity and mortality, it accounts for about 90% of cancer deaths. Cancer treatment has improved significantly, due to early detection and inhibition of cancer growth. The ability to invade and migrate is important in malignant tumor cells. The study of cell migration is valuable in cancer diagnosis, prognosis, drug development and treatment. New methods are available to investigate the invasion, migration and the activity of enzymes involved in the invasion process in the laboratory. The effectiveness and efficacy of various anti-cancer drugs and compounds can be studied using these methods in laboratory and animal models. Conclusion: In this paper, we offer a summary of in-vitro migration assays, including the transwell migration assay, scratch wound assay, microfluidic chamber assay, exclusion zone assay, fence assay, micro carrier bead assay, spheroid migration assay and in-vivo approach, Chick chorioallantoic membrane (CAM) assay. This review also provides an overview of methods, In situ Zymography, ELISA, and FRET based measurement of MMP activity and Substrate Zymography for measuring the level of metalloproteinase enzyme as the major enzyme in the degradation of extracellular matrix.

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APA: Copy

GOLESTANI, A., Abdollahipour Haghighi, R., TAKHSHID, M.A., & ARABSOLGHAR, R.. (2019). New Techniques and Methods in the Study of the Invasion, Cell Migration and MMPs Activity in Vitro and in Animal Models. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 8(4 ), 1000-1011. SID. https://sid.ir/paper/203977/en

Vancouver: Copy

GOLESTANI A., Abdollahipour Haghighi R., TAKHSHID M.A., ARABSOLGHAR R.. New Techniques and Methods in the Study of the Invasion, Cell Migration and MMPs Activity in Vitro and in Animal Models. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2019;8(4 ):1000-1011. Available from: https://sid.ir/paper/203977/en

IEEE: Copy

A. GOLESTANI, R. Abdollahipour Haghighi, M.A. TAKHSHID, and R. ARABSOLGHAR, “New Techniques and Methods in the Study of the Invasion, Cell Migration and MMPs Activity in Vitro and in Animal Models,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 8, no. 4 , pp. 1000–1011, 2019, [Online]. Available: https://sid.ir/paper/203977/en

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