The Comparison of Nanoparticle Adjuvant with the Montanide Adjuvant for Hyper-Immunization to Produce Anti-Snakebite Serum

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Maljaee P.; ZOLFAGHARIAN HOSSEIN; BABAIE M.; MOHAMMADPOUR DOUNIGHI N.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Advanced Biomedical Sciences Year:2018 | Volume:8 | Issue:1 Page(s): 674-682

Download Full-Text

Persian Verion

View:

362

Download:

Cites:

Information Journal Paper

Title

The Comparison of Nanoparticle Adjuvant with the Montanide Adjuvant for Hyper-Immunization to Produce Anti-Snakebite Serum

Author(s)

Maljaee P. | ZOLFAGHARIAN HOSSEIN | BABAIE M. | MOHAMMADPOUR DOUNIGHI N. | Issue Writer Certificate

Keywords

Nanoparticle adjuvantQ1

Naja naja oxianaQ1

Poly methyl methacrylateQ1

aluminum phosphateQ1

MontanideQ1

Abstract

Background & Objective: Currently selection and use of Nanoparticle adjuvant is very important. Due to the lack of effective anti-snakebite serums to treat it and high cost of purchasing external antisnakebite serums, preparation of suitable internal nanoparticles to produce hyper-immunization plasma has become very important. In order to minimize the disadvantages associated with traditionally used adjuvants in ovines and to produce potent antivenum, a comparison was made between various adjuvants for their immune-potentiation capacity and safety. Material & Methods: The present study was conducted in 15 sheep, divided into three groups and hyper-immunized using crude venom of cobra snake (Naja naja oxiana) along with three adjuvants, Montanide, aluminum phosphate and Poly methyl methacrylate through subcutaneous route at intervals of a week. Periodic standard safety assessments were done. Results: The neutralization activity (LD50) of pooled sera samples by 9th week, obtained with aluminum phosphate, Montanide and Poly methyl methacrylate groups were 1. 5, 2. 2 and 2 LD50/ml respectively. The sheep of Poly methyl methacrylate group showed minimum local reactions at injection site, while sheep from other two groups exhibited moderate reactions. However, these were transient and reabsorbed or healed subsequently. Conclusion: Poly methyl methacrylate Nanoparticle adjuvant could be a possible alternative to the emulsion adjuvants for primary phase of immunization in antivenomous preparation considering its acceptable immunopotentiation capacity and safety in donor animals.

Cites

No record.

References

Cite

APA: Copy

Maljaee, P., ZOLFAGHARIAN, HOSSEIN, BABAIE, M., & MOHAMMADPOUR DOUNIGHI, N.. (2018). The Comparison of Nanoparticle Adjuvant with the Montanide Adjuvant for Hyper-Immunization to Produce Anti-Snakebite Serum. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 8(1 ), 674-682. SID. https://sid.ir/paper/204047/en

Vancouver: Copy

Maljaee P., ZOLFAGHARIAN HOSSEIN, BABAIE M., MOHAMMADPOUR DOUNIGHI N.. The Comparison of Nanoparticle Adjuvant with the Montanide Adjuvant for Hyper-Immunization to Produce Anti-Snakebite Serum. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2018;8(1 ):674-682. Available from: https://sid.ir/paper/204047/en

IEEE: Copy

P. Maljaee, HOSSEIN ZOLFAGHARIAN, M. BABAIE, and N. MOHAMMADPOUR DOUNIGHI, “The Comparison of Nanoparticle Adjuvant with the Montanide Adjuvant for Hyper-Immunization to Produce Anti-Snakebite Serum,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 8, no. 1 , pp. 674–682, 2018, [Online]. Available: https://sid.ir/paper/204047/en

Related Journal Papers