COMPARING SERUM VISFATIN LEVELS IN RESTRICTED DIET, TYPE 2 DIABETIC, AND INSULIN RESISTANT RATS AND THOSE IN NORMAL RATS: THE RELATION OF SERUM VISFATIN LEVELS WITH SERUM GLUCOSE LEVEL AND LIPID PROFILE

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GHAFFARI M.A.; RAFIEI E.; SALEMI Z.; GOODARZI M.T.; GHASEMI M.

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Journal: Journal of Advanced Biomedical Sciences Year:2015 | Volume:5 | Issue:3 Page(s): 435-443

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Title

COMPARING SERUM VISFATIN LEVELS IN RESTRICTED DIET, TYPE 2 DIABETIC, AND INSULIN RESISTANT RATS AND THOSE IN NORMAL RATS: THE RELATION OF SERUM VISFATIN LEVELS WITH SERUM GLUCOSE LEVEL AND LIPID PROFILE

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Keywords

TYPE 2 DIABETESQ2

INSULIN RESISTANTQ2

RATQ2

VISFATINQ1

HOMA-IRQ1

Abstract

Background & Objectives: Adipose tissue secretes adipokines VISFATIN as a new adipokine which has an important role in homeostasis of energy and glucose metabolism. In the present study, serum VISFATIN levels in restricted diet, type 2 diabetic, and INSULIN RESISTANT RATs have been measured and compared to the control group. The relationship between VISFATIN and blood sugar, lipid profile, insulin, and HOMA-IR in these groups have been also investigated.Materials & Methods: 32 male Wistar RATs were divided into 4 groups (8 RATs in each group) as control (group 1), restricted diet (group 2), induced type 2 diabetic RATs (group 3), and INSULIN RESISTANT RATs (group 4). After 6 weeks, the animal weights and other biochemical factors such as FBS (Fasting Blood Sugar), lipid profile, insulin, and VISFATIN were measured. The results of this study were analyzed using SPSS16 and then examined and reported as ± average of standard deviation. The values with p< 0.05 were considered statistically significant.Results: In the present study, FBS, Triglyceride, VISFATIN, and HOMA-IR increased significantly in type 2 diabetic RATs and INSULIN RESISTANT group.Conclusion: Restricted diet or reduced energy level kept the insulin level low and therefore reduced serum VISFATIN level .The improvement of serum glucose level and lipid profile was better in this group.

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APA: Copy

GHAFFARI, M.A., RAFIEI, E., SALEMI, Z., GOODARZI, M.T., & GHASEMI, M.. (2015). COMPARING SERUM VISFATIN LEVELS IN RESTRICTED DIET, TYPE 2 DIABETIC, AND INSULIN RESISTANT RATS AND THOSE IN NORMAL RATS: THE RELATION OF SERUM VISFATIN LEVELS WITH SERUM GLUCOSE LEVEL AND LIPID PROFILE. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 5(3), 435-443. SID. https://sid.ir/paper/204069/en

Vancouver: Copy

GHAFFARI M.A., RAFIEI E., SALEMI Z., GOODARZI M.T., GHASEMI M.. COMPARING SERUM VISFATIN LEVELS IN RESTRICTED DIET, TYPE 2 DIABETIC, AND INSULIN RESISTANT RATS AND THOSE IN NORMAL RATS: THE RELATION OF SERUM VISFATIN LEVELS WITH SERUM GLUCOSE LEVEL AND LIPID PROFILE. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2015;5(3):435-443. Available from: https://sid.ir/paper/204069/en

IEEE: Copy

M.A. GHAFFARI, E. RAFIEI, Z. SALEMI, M.T. GOODARZI, and M. GHASEMI, “COMPARING SERUM VISFATIN LEVELS IN RESTRICTED DIET, TYPE 2 DIABETIC, AND INSULIN RESISTANT RATS AND THOSE IN NORMAL RATS: THE RELATION OF SERUM VISFATIN LEVELS WITH SERUM GLUCOSE LEVEL AND LIPID PROFILE,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 5, no. 3, pp. 435–443, 2015, [Online]. Available: https://sid.ir/paper/204069/en

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